Detailed information of TA system TA155912

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 299059..299630
• Replicon: chromosome
• Accession: NZ_CP053072
• Organism: Bifidobacterium adolescentis strain PRL2019

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HJ592_RS01165
• Protein ID: WP_003807675.1
• Coordinates: 299059..299358 (-)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A0C2Z6P7
• Locus tag: HJ592_RS01170
• Protein ID: WP_034984155.1
• Coordinates: 299358..299630 (-)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HJ592_RS01155	295743..296471	+	729	WP_038443985.1	type 1 glutamine amidotransferase	-
HJ592_RS01160	296783..298960	+	2178	WP_085461749.1	ABC-F family ATP-binding cassette domain-containing protein	-
HJ592_RS01165	299059..299358	-	300	WP_003807675.1	type II toxin-antitoxin system YafQ family toxin	Toxin
HJ592_RS01170	299358..299630	-	273	WP_034984155.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
HJ592_RS01175	299744..300580	-	837	WP_085461750.1	hypothetical protein	-
HJ592_RS01180	300764..301303	+	540	WP_003807679.1	hypothetical protein	-
HJ592_RS01185	301367..301591	+	225	WP_198553918.1	DUF2992 family protein	-
HJ592_RS01190	301834..302229	+	396	WP_029575615.1	SRPBCC family protein	-
HJ592_RS01195	302256..302576	+	321	WP_004612621.1	TfoX/Sxy family protein	-
HJ592_RS01200	303366..304520	-	1155	WP_046998989.1	ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (7-98)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-69)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11662.09 Da
• Isoelectric Point: 8.0955

>T155912 WP_003807675.1 NZ_CP053072:c299358-299059 [Bifidobacterium adolescentis]
MGRLTADFAKAFSRDLKKNAKRRNWNLTELEKVIDLVVENTPETLEELRRRHNMHTLSGNWRGRYECHVANAGDWLVIWS
SNDSVAFFERTGSHDELFR

Nucleotide

• Length: 300 bp

>T155912 NZ_CP068819:c4986512-4986201 [Escherichia coli]
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGACCGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTGTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 9714.91 Da
• Isoelectric Point: 4.5535

>AT155912 WP_034984155.1 NZ_CP053072:c299630-299358 [Bifidobacterium adolescentis]
MSASTLTIRMDDELKRSAADVAEYYGLDLSSVVRAVFKQMVNTGRIPLTFAPEEPNGESLNAAAEADSFMASGKTGRFTN
GHDLLEAAMR

Nucleotide

• Length: 273 bp

>AT155912 NZ_CP068819:c4986200-4985910 [Escherichia coli]
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACACCCTTC
ACGGACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGAAC
TTATTTCCGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACTGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAGGCACTTAACCGTTAG

Structures

Antitoxin

• AlphaFold DB: A0A0C2Z6P7