Detailed information of TA system TA155906

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsdAT/-
• Location: 2160984..2161498
• Replicon: chromosome
• Accession: NZ_CP053070
• Organism: Staphylococcus aureus strain HL20709 isolate HL20709

Toxin (Protein)

• Gene name: TsdT
• Uniprot ID: T1YA99
• Locus tag: HH313_RS10710
• Protein ID: WP_000581792.1
• Coordinates: 2160984..2161193 (-)
• Length: 70 a.a.

Antitoxin (Protein)

• Gene name: TsdA
• Uniprot ID: A0A0D1GBN9
• Locus tag: HH313_RS10715
• Protein ID: WP_000138934.1
• Coordinates: 2161205..2161498 (-)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HH313_RS10690	2156492..2157850	-	1359	WP_000611468.1	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase	-
HH313_RS10695	2157865..2158935	-	1071	WP_000159641.1	D-alanine--D-alanine ligase	-
HH313_RS10700	2159253..2160455	+	1203	WP_001109939.1	rod shape-determining protein RodA	-
HH313_RS10705	2160719..2160856	-	138	WP_000828354.1	hypothetical protein	-
HH313_RS10710	2160984..2161193	-	210	WP_000581792.1	heavy-metal-associated domain-containing protein	Toxin
HH313_RS10715	2161205..2161498	-	294	WP_000138934.1	copper-sensing transcriptional repressor CsoR	Antitoxin
HH313_RS10720	2161664..2163148	+	1485	WP_000571549.1	cardiolipin synthase	-
HH313_RS10725	2163176..2163823	+	648	WP_001187610.1	HD domain-containing protein	-
HH313_RS10730	2164638..2165510	-	873	WP_000725802.1	membrane protein insertase YidC	-
HH313_RS10735	2165596..2166237	-	642	WP_000483147.1	thiamine phosphate synthase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Heavy metal-associated domain, HMA (23-66)

Antitoxin

• Metal-sensitive transcriptional repressor (3-95)

Sequences

Toxin

Protein

• Length: 70 a.a.
• Molecular weight: 7843.77 Da
• Isoelectric Point: 4.1008

>T155906 WP_000581792.1 NZ_CP053070:c2161193-2160984 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Nucleotide

• Length: 210 bp

>T155906 NZ_CP068819:c4326887-4326678 [Escherichia coli]
ATGGTTGATTATCCAAAACGTGATGCTATTTCCAACATCAACGCTATAATTGTAGATACATTTTTGTATATACAATTAGG
GATGGCAACTATGCCAATGGAGTTTGAATGGAATGCAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTG
AAGATGCGGTGTTAGTGCTTGATGATCCACAACGAACGGAGCCGCTATGA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 11185.77 Da
• Isoelectric Point: 6.2243

>AT155906 WP_000138934.1 NZ_CP053070:c2161498-2161205 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Nucleotide

• Length: 294 bp

>AT155906 NZ_CP068819:c4326681-4326379 [Escherichia coli]
ATGAGCATGGTTAAACATAAACGAGGGACCTCCTCTACACTCGATGTGCAGCATGAGGCCGAACTGAAGGTGCTGGCGAA
CAAATTCGACGAGGATATTGATTACAGCGACATCCCATCTTCCAGCGATGAGCAATGGTCTAACGCAGAACGCGGTAAGT
TTTATCGGCCATTGAAAACTCAGGCTTCGGTGCGTATTGATGCTGATGTGATGGAATGGTTGAAGCGACCAGGTAAAGGC
TATCAAACTCGCCTGAACGCAATTTTACGTGAAGCGATGCTGCGCGATCAGAACAAAAAATAA

Structures

Toxin

• PDB: 6FF1

Antitoxin

• AlphaFold DB: A0A0D1GBN9