Detailed information of TA system TA155905

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(toxin)
• Location: 2141244..2141773
• Replicon: chromosome
• Accession: NZ_CP053070
• Organism: Staphylococcus aureus strain HL20709 isolate HL20709

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: HH313_RS10620
• Protein ID: WP_000621175.1
• Coordinates: 2141244..2141606 (-)
• Length: 121 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: T1YCG8
• Locus tag: HH313_RS10625
• Protein ID: WP_000948331.1
• Coordinates: 2141603..2141773 (-)
• Length: 57 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HH313_RS10600	2138223..2138993	-	771	WP_001041107.1	RNA polymerase sigma factor SigB	-
HH313_RS10605	2138968..2139447	-	480	WP_001190825.1	anti-sigma B factor RsbW	-
HH313_RS10610	2139449..2139775	-	327	WP_001052491.1	anti-sigma factor antagonist	-
HH313_RS10615	2139894..2140895	-	1002	WP_000390829.1	PP2C family protein-serine/threonine phosphatase	-
HH313_RS10620	2141244..2141606	-	363	WP_000621175.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
HH313_RS10625	2141603..2141773	-	171	WP_000948331.1	type II toxin-antitoxin system antitoxin MazE	Antitoxin
HH313_RS10630	2141858..2143006	-	1149	WP_001280702.1	alanine racemase	-
HH313_RS10635	2143072..2143431	-	360	WP_000581194.1	holo-ACP synthase	-
HH313_RS10640	2143435..2143926	-	492	WP_001205915.1	PH domain-containing protein	-
HH313_RS10645	2143913..2145496	-	1584	WP_001294642.1	PH domain-containing protein	-
HH313_RS10650	2145489..2145968	-	480	WP_001287083.1	hypothetical protein	-
HH313_RS10655	2146177..2146737	-	561	WP_001092405.1	K(+)-transporting ATPase subunit C	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (3-110)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 121 a.a.
• Molecular weight: 13441.69 Da
• Isoelectric Point: 10.1654

>T155905 WP_000621175.1 NZ_CP053070:c2141606-2141244 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Nucleotide

• Length: 363 bp

>T155905 NZ_CP068819:c3985354-3984956 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCGTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGTGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAGCCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGAAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin

Protein

• Length: 57 a.a.
• Molecular weight: 6251.78 Da
• Isoelectric Point: 3.8305

>AT155905 WP_000948331.1 NZ_CP053070:c2141773-2141603 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Nucleotide

• Length: 171 bp

>AT155905 NZ_CP068819:c3985650-3985357 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAATCCAGCAAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CAGAACAAGAGGAGAAAAAACTGGTGAAGGCGCGCTTCCGTCCGAGTGCCGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Structures

Antitoxin

• AlphaFold DB: A0A0E0VRZ1