155901

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) TscAT/-
Location 876039..876571 Replicon chromosome
Accession NZ_CP053070
Organism Staphylococcus aureus strain HL20709 isolate HL20709

Toxin (Protein)


Gene name TscT Uniprot ID Q93CD4
Locus tag HH313_RS04140 Protein ID WP_001103942.1
Coordinates 876251..876571 (+) Length 107 a.a.

Antitoxin (Protein)


Gene name TscA Uniprot ID -
Locus tag HH313_RS04135 Protein ID WP_001058486.1
Coordinates 876039..876248 (+) Length 70 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HH313_RS04090 871059..872279 - 1221 WP_000266157.1 site-specific integrase -
HH313_RS04095 872367..873095 - 729 WP_000733774.1 staphylococcal enterotoxin type K -
HH313_RS04100 873119..873847 - 729 WP_001033318.1 staphylococcal enterotoxin type Q -
HH313_RS04105 873917..874348 - 432 WP_001228759.1 hypothetical protein -
HH313_RS04110 874365..874823 - 459 WP_000281657.1 ImmA/IrrE family metallo-endopeptidase -
HH313_RS04115 874835..875167 - 333 WP_001260004.1 helix-turn-helix transcriptional regulator -
HH313_RS04120 875360..875623 + 264 WP_000243851.1 helix-turn-helix domain-containing protein -
HH313_RS04125 875616..875888 + 273 WP_000091731.1 helix-turn-helix domain-containing protein -
HH313_RS04130 875900..876046 + 147 WP_000784875.1 hypothetical protein -
HH313_RS04135 876039..876248 + 210 WP_001058486.1 hypothetical protein Antitoxin
HH313_RS04140 876251..876571 + 321 WP_001103942.1 DUF1474 family protein Toxin
HH313_RS04145 876635..877504 + 870 WP_001002732.1 primase alpha helix C-terminal domain-containing protein -
HH313_RS04150 877521..878990 + 1470 WP_000390454.1 virulence-associated E family protein -
HH313_RS04155 879276..879638 + 363 WP_001039168.1 hypothetical protein -
HH313_RS04160 879640..879924 + 285 WP_000998181.1 hypothetical protein -
HH313_RS04165 879921..880562 + 642 WP_001019764.1 hypothetical protein -
HH313_RS04170 881079..881420 + 342 WP_001190615.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - selk / selq / seb 853024..886371 33347


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-98)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 107 a.a.        Molecular weight: 12694.22 Da        Isoelectric Point: 4.7419

>T155901 WP_001103942.1 NZ_CP053070:876251-876571 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKQKINDVATKHAWFVEDRFVKNELETKREHINFSASYLEHRIQNEHTVELLHVYLKEFSELIQKF
HEIEKASSENFDEESDDAKNSIKVAE

Download         Length: 321 bp

>T155901 NZ_CP068819:3058751-3059245 [Escherichia coli]
ATGATTCAGGCCCCCGAGCCACTCATGGCAAGGCATCAATTCACCTCTTTTTGCTCGGGAGTAGAAACGATGGATAACTG
GCTAAAGCAGAGAGCCCTAAAAAATCAGCTTGCCGGCGCATCACGTACATTTGTTAGCTGTGATACGTATAGCAACGTTT
TGGCATATTATTCGCTTGCTTCCAGCGCCGTTGAAACGTATGTCGCGACAGGACGATTTCGCCGAAATATGCCAGAACCG
ATCCCTGTTGTAGTACTTGGTCGTCTGGCAATAGATAAATCATTACAGGGTCAGGGCATCGGTCGTGCGATGGTCAGAGA
TGCCGGTCTACGAGTACTACAGGCGGCTGAAGTCATTGGTATTCGCGGAATGTTGGTCCATGCGTTATCAGACCAGGCCC
GTGAGTTTTATCTGCGAGTGGGGTTTGAACCATCGCCTGTCGATTCTATGATACTGATGGCAACATTGGCTGATTTGCAG
GAATGTCTTAAATAG

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 8252.31 Da        Isoelectric Point: 4.3718

>AT155901 WP_001058486.1 NZ_CP053070:876039-876248 [Staphylococcus aureus]
MNNEQKEVIEHLVYQLELSVMNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Download         Length: 210 bp

>AT155901 NZ_CP068819:3058461-3058754 [Escherichia coli]
ATGCCAGCAGCCAATAACATTCCAACCAGGCGCGAATCTTTAAATTTGCGCATAAAACCCGCAGAACGCGATCTTATTGA
CCGGGCCGCTAAAGCCCGAGGAAAAAATCGCACCGAATTTGTCCTTGAGGCCGCCAGAGCCGCAGCTGAAGAGGCGCTCA
TTGAGCAGAGAATTTTCAGGATCGATTCTGATGATTACCAGCTATTTTTGAATCGTCTGGATCAGCCCCCCGCGCCCAAT
GCTGCATTACGCAAAACCATGCAAACACCCGCGCCGTGGGAGCAAAAAAAATGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB Q93CD4


Antitoxin

Source ID Structure

References