Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | TsaAT/- |
Location | 858344..858821 | Replicon | chromosome |
Accession | NZ_CP053070 | ||
Organism | Staphylococcus aureus strain HL20709 isolate HL20709 |
Toxin (Protein)
Gene name | TsaT | Uniprot ID | T1Y7S2 |
Locus tag | HH313_RS03995 | Protein ID | WP_000052076.1 |
Coordinates | 858344..858532 (-) | Length | 63 a.a. |
Antitoxin (Protein)
Gene name | TsaA | Uniprot ID | T1Y6P8 |
Locus tag | HH313_RS04000 | Protein ID | WP_001059690.1 |
Coordinates | 858561..858821 (-) | Length | 87 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
HH313_RS03965 | 854382..854852 | + | 471 | WP_000824462.1 | hypothetical protein | - |
HH313_RS03970 | 855193..855879 | + | 687 | WP_001823812.1 | thermonuclease family protein | - |
HH313_RS03975 | 856236..856436 | + | 201 | WP_001059082.1 | cold-shock protein | - |
HH313_RS03980 | 856935..857153 | - | 219 | WP_000005888.1 | hypothetical protein | - |
HH313_RS03985 | 857215..857499 | - | 285 | WP_001004397.1 | hypothetical protein | - |
HH313_RS03990 | 857587..858156 | - | 570 | WP_001106657.1 | hypothetical protein | - |
HH313_RS03995 | 858344..858532 | - | 189 | WP_000052076.1 | hypothetical protein | Toxin |
HH313_RS04000 | 858561..858821 | - | 261 | WP_001059690.1 | hypothetical protein | Antitoxin |
HH313_RS04005 | 859162..859365 | + | 204 | WP_000145163.1 | sterile alpha motif-like domain-containing protein | - |
HH313_RS04010 | 859362..859598 | - | 237 | WP_000368687.1 | hypothetical protein | - |
HH313_RS04015 | 859823..860404 | + | 582 | WP_001140697.1 | phosphoglycerate mutase family protein | - |
HH313_RS04020 | 860477..861094 | - | 618 | WP_000255554.1 | LysE/ArgO family amino acid transporter | - |
HH313_RS04025 | 861250..861744 | - | 495 | WP_000569881.1 | GNAT family N-acetyltransferase | - |
HH313_RS04030 | 862143..862565 | - | 423 | WP_000974455.1 | organic hydroperoxide resistance protein | - |
HH313_RS04035 | 862713..863429 | + | 717 | WP_000150029.1 | type I 3-dehydroquinate dehydratase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Prophage | - | selk / selq / seb | 853024..886371 | 33347 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 63 a.a. Molecular weight: 7142.82 Da Isoelectric Point: 9.9971
>T155900 WP_000052076.1 NZ_CP053070:c858532-858344 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL
Download Length: 189 bp
>T155900 NZ_CP068819:2883219-2883326 [Escherichia coli]
ATGACGCTCACGCAGTTTGCCATGACTTTCTGGCACGACTTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA
ATGACGCTCACGCAGTTTGCCATGACTTTCTGGCACGACTTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA
Antitoxin
Download Length: 87 a.a. Molecular weight: 9940.09 Da Isoelectric Point: 4.0624
>AT155900 WP_001059690.1 NZ_CP053070:c858821-858561 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG
Download Length: 261 bp
>AT155900 NZ_CP068819:c2883169-2883106 [Escherichia coli]
TCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTATACCTCTCAACGTGCGGGGGTTTTCT
TCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTATACCTCTCAACGTGCGGGGGTTTTCT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0E0VP18 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0E0VN56 |