Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 858344..858821 Replicon chromosome
Accession NZ_CP053070
Organism Staphylococcus aureus strain HL20709 isolate HL20709

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag HH313_RS03995 Protein ID WP_000052076.1
Coordinates 858344..858532 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag HH313_RS04000 Protein ID WP_001059690.1
Coordinates 858561..858821 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HH313_RS03965 854382..854852 + 471 WP_000824462.1 hypothetical protein -
HH313_RS03970 855193..855879 + 687 WP_001823812.1 thermonuclease family protein -
HH313_RS03975 856236..856436 + 201 WP_001059082.1 cold-shock protein -
HH313_RS03980 856935..857153 - 219 WP_000005888.1 hypothetical protein -
HH313_RS03985 857215..857499 - 285 WP_001004397.1 hypothetical protein -
HH313_RS03990 857587..858156 - 570 WP_001106657.1 hypothetical protein -
HH313_RS03995 858344..858532 - 189 WP_000052076.1 hypothetical protein Toxin
HH313_RS04000 858561..858821 - 261 WP_001059690.1 hypothetical protein Antitoxin
HH313_RS04005 859162..859365 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
HH313_RS04010 859362..859598 - 237 WP_000368687.1 hypothetical protein -
HH313_RS04015 859823..860404 + 582 WP_001140697.1 phosphoglycerate mutase family protein -
HH313_RS04020 860477..861094 - 618 WP_000255554.1 LysE/ArgO family amino acid transporter -
HH313_RS04025 861250..861744 - 495 WP_000569881.1 GNAT family N-acetyltransferase -
HH313_RS04030 862143..862565 - 423 WP_000974455.1 organic hydroperoxide resistance protein -
HH313_RS04035 862713..863429 + 717 WP_000150029.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - selk / selq / seb 853024..886371 33347


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T155900 WP_000052076.1 NZ_CP053070:c858532-858344 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T155900 NZ_CP068819:2883219-2883326 [Escherichia coli]
ATGACGCTCACGCAGTTTGCCATGACTTTCTGGCACGACTTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT155900 WP_001059690.1 NZ_CP053070:c858821-858561 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT155900 NZ_CP068819:c2883169-2883106 [Escherichia coli]
TCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTATACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References