Detailed information of TA system TA155894

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 41920..42445
• Replicon: plasmid p28321a-2
• Accession: NZ_CP053054
• Organism: Salmonella enterica subsp. enterica serovar Typhimurium strain CVM 28321-a

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: I3W3D5
• Locus tag: HFS61_RS25330
• Protein ID: WP_001159863.1
• Coordinates: 42140..42445 (+)
• Length: 102 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: M7S5D0
• Locus tag: HFS61_RS25325
• Protein ID: WP_000813641.1
• Coordinates: 41920..42138 (+)
• Length: 73 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HFS61_RS25300	37207..37588	+	382	Protein_40	YgiW/YdeI family stress tolerance OB fold protein	-
HFS61_RS25305	37757..38201	+	445	Protein_41	site-specific integrase	-
HFS61_RS25310	38460..39449	-	990	WP_001527061.1	RepB family plasmid replication initiator protein	-
HFS61_RS25315	39943..40239	-	297	WP_001687482.1	hypothetical protein	-
HFS61_RS25320	40723..41244	-	522	WP_010999942.1	hypothetical protein	-
HFS61_RS25325	41920..42138	+	219	WP_000813641.1	type II toxin-antitoxin system antitoxin CcdA	Antitoxin
HFS61_RS25330	42140..42445	+	306	WP_001159863.1	type II toxin-antitoxin system toxin CcdB	Toxin
HFS61_RS25335	42447..42737	+	291	WP_001266176.1	hypothetical protein	-
HFS61_RS25340	42734..43255	+	522	WP_000198608.1	hypothetical protein	-
HFS61_RS25345	43290..44072	+	783	WP_000082169.1	site-specific integrase	-
HFS61_RS25350	44081..44794	+	714	Protein_50	EAL domain-containing protein	-
HFS61_RS25355	44798..45307	+	510	WP_001541544.1	CaiF/GrlA family transcriptional regulator	-
HFS61_RS25360	45301..45786	+	486	WP_000905606.1	membrane protein	-
HFS61_RS25365	46063..46350	-	288	WP_071530243.1	hypothetical protein	-
HFS61_RS25370	46506..47066	+	561	WP_000900095.1	inverse autotransporter beta domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..94046	94046

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 102 a.a.
• Molecular weight: 13091.77 Da
• Isoelectric Point: 12.8043

>T155894 WP_001159863.1 NZ_CP053054:42140-42445 [Salmonella enterica subsp. enterica serovar Typhimurium]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKK

Nucleotide

• Length: 306 bp

>T155894 NZ_CP068819:2019784-2020038 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAGTCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin

Protein

• Length: 73 a.a.
• Molecular weight: 9374.72 Da
• Isoelectric Point: 12.6573

>AT155894 WP_000813641.1 NZ_CP053054:41920-42138 [Salmonella enterica subsp. enterica serovar Typhimurium]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Nucleotide

• Length: 219 bp

>AT155894 NZ_CP068819:2019536-2019787 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Structures

Toxin

• AlphaFold DB: I3W3D5

Antitoxin

• AlphaFold DB: A0A656ICA6