Detailed information of TA system TA155892

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-DnaT
• Location: 21287..21809
• Replicon: plasmid p30155-2
• Accession: NZ_CP053050
• Organism: Salmonella enterica subsp. enterica serovar Derby strain CVM 30155

Toxin (Protein)

• Gene name: relE
• Uniprot ID: D0QMR1
• Locus tag: HFS97_RS24660
• Protein ID: WP_000220561.1
• Coordinates: 21528..21809 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: G3CAG1
• Locus tag: HFS97_RS24655
• Protein ID: WP_000121743.1
• Coordinates: 21287..21538 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HFS97_RS24635	17575..17997	-	423	WP_000202949.1	hypothetical protein	-
HFS97_RS24640	18068..18511	-	444	WP_053220570.1	hypothetical protein	-
HFS97_RS24645	18515..19348	-	834	WP_021515684.1	replication initiation protein	-
HFS97_RS24650	19353..20222	-	870	WP_032152971.1	replication initiation protein	-
HFS97_RS24655	21287..21538	+	252	WP_000121743.1	plasmid stabilization protein	Antitoxin
HFS97_RS24660	21528..21809	+	282	WP_000220561.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HFS97_RS24665	22158..22673	+	516	WP_001025387.1	J domain-containing protein	-
HFS97_RS24670	22747..23295	+	549	WP_001178641.1	hypothetical protein	-
HFS97_RS24675	23361..23573	+	213	WP_001446884.1	hypothetical protein	-
HFS97_RS24680	23563..23805	+	243	WP_000008708.1	hypothetical protein	-
HFS97_RS24685	23899..24228	+	330	WP_000866654.1	hypothetical protein	-
HFS97_RS24690	24520..24666	+	147	WP_001567307.1	hypothetical protein	-
HFS97_RS24695	24683..24955	+	273	WP_000167280.1	hypothetical protein	-
HFS97_RS24700	25212..25286	+	75	Protein_30	DNA distortion polypeptide 3	-
HFS97_RS24705	25281..25826	+	546	WP_001426313.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..54008	54008

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, mRNA interferase HigB (22-93)

Antitoxin

• Cro/C1-type helix-turn-helix domain (85-138)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 12066.38 Da
• Isoelectric Point: 12.7685

>T155892 WP_000220561.1 NZ_CP053050:21528-21809 [Salmonella enterica subsp. enterica serovar Derby]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKK

Nucleotide

• Length: 282 bp

>T155892 NZ_CP068819:c1245531-1245220 [Escherichia coli]
ATGCACATCATTTCGAAAGCGCCATTTGAAGAGTGTGCGCGCAAATATCCTAACGACGCTCTGGCTCTACACTCATTGTA
TCGGGTTATTAAGGAAACGGATTTTTCTACACCAGAAGAAATGCGAACGGCGTTTCCTAACCTCGACAATTTTAAATATC
GCAACAAATGGTACGTTCTGGATGTCGGCGGGAACAATCTTAGGGTTATTGCCTACATAAACTTTGTTAATAAGCGGTTC
TTTGTGAAGCACATAACGAATCACGCAGAGTATGACAAACTGACACGTTACTACAGAGAGAACAAAGAATGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 10784.64 Da
• Isoelectric Point: 12.7191

>AT155892 WP_000121743.1 NZ_CP053050:21287-21538 [Salmonella enterica subsp. enterica serovar Derby]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKK

Nucleotide

• Length: 252 bp

>AT155892 NZ_CP068819:c1245223-1244804 [Escherichia coli]
ATGACTGCTAATGCTGCACGCGCTGTTAAAGCAACAAGAGAACTGGTCAATGCAGTCCCCTTTCTGGGAGGCAGTGACTC
AGAAGATGATTATCGTGAAGCACTGGAACTGGTCGAATATTTGATTGAAGAAGATGACACCAATCCACTTATCGACTTTC
TGGCGAGCCGCATTGCAGAATATGAAAACAACAACGAAAAGTTTGCAGAGTTCGACAAAGCCGTTGCAGCAATGCCGGTT
GGCGTGGCCTTACTTCGTACGCTGATTGATCAACATAATTTGACCTATGCGGATTTGAAGAACGAAATCGGCTCTAAATC
TCTGGTCAGTCAGATTTTGTCTGGGCAACGATCCCTGACGATATCCCATATTAAGGCACTTTCAGCCCGATTTGGCGTTA
AGCCGGAATGGTTTCTTTGA

Structures

Toxin

• AlphaFold DB: A0A3S5I302

Antitoxin

• AlphaFold DB: A0A3S5I301