Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | relBE/ParE-DnaT |
Location | 8447..8969 | Replicon | plasmid pHNCF11W-tetX4 |
Accession | NZ_CP053047 | ||
Organism | Escherichia fergusonii strain HNCF11W |
Toxin (Protein)
Gene name | relE | Uniprot ID | G3CAN5 |
Locus tag | HG538_RS22880 | Protein ID | WP_000220560.1 |
Coordinates | 8447..8728 (-) | Length | 94 a.a. |
Antitoxin (Protein)
Gene name | relB | Uniprot ID | G3CAG1 |
Locus tag | HG538_RS22885 | Protein ID | WP_000121743.1 |
Coordinates | 8718..8969 (-) | Length | 84 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
HG538_RS22835 | 3456..3947 | - | 492 | WP_000872475.1 | transcription termination factor NusG | - |
HG538_RS22840 | 4308..5465 | - | 1158 | WP_000538023.1 | hypothetical protein | - |
HG538_RS22845 | 5468..6013 | - | 546 | WP_038976855.1 | hypothetical protein | - |
HG538_RS22850 | 6340..6612 | - | 273 | WP_000160399.1 | hypothetical protein | - |
HG538_RS22855 | 6625..6774 | - | 150 | WP_000003880.1 | hypothetical protein | - |
HG538_RS22860 | 7061..7390 | - | 330 | WP_000866648.1 | hypothetical protein | - |
HG538_RS22865 | 7483..7698 | - | 216 | WP_001180116.1 | hypothetical protein | - |
HG538_RS22870 | 7688..7933 | - | 246 | WP_000356546.1 | hypothetical protein | - |
HG538_RS22875 | 7978..8301 | - | 324 | WP_001181903.1 | hypothetical protein | - |
HG538_RS22880 | 8447..8728 | - | 282 | WP_000220560.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
HG538_RS22885 | 8718..8969 | - | 252 | WP_000121743.1 | plasmid stabilization protein | Antitoxin |
HG538_RS22890 | 10225..11061 | + | 837 | WP_001050931.1 | replication initiation protein | - |
HG538_RS22895 | 11101..11547 | + | 447 | WP_001074386.1 | hypothetical protein | - |
HG538_RS22900 | 11684..12037 | + | 354 | WP_000876434.1 | hypothetical protein | - |
HG538_RS22905 | 12097..13065 | - | 969 | WP_166501310.1 | IS5 family transposase | - |
HG538_RS22910 | 13067..13360 | - | 294 | WP_015060510.1 | hypothetical protein | - |
HG538_RS22915 | 13376..13606 | - | 231 | WP_000051064.1 | partitioning protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Non-Mobilizable plasmid | aadA2 / lnu(F) / tet(X4) / floR / tet(A) / blaSHV-12 | - | 1..57105 | 57105 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 94 a.a. Molecular weight: 11005.83 Da Isoelectric Point: 10.5938
>T155891 WP_000220560.1 NZ_CP053047:c8728-8447 [Escherichia fergusonii]
MTYELAFDRRALKEWQKLGHTIREQFKKKLAERLENPRVPAARLHGHADRYKIKLRASGYRLVYQVIDEKVVLLVIAVGR
RESSEVYQIADLR
MTYELAFDRRALKEWQKLGHTIREQFKKKLAERLENPRVPAARLHGHADRYKIKLRASGYRLVYQVIDEKVVLLVIAVGR
RESSEVYQIADLR
Download Length: 282 bp
>T155891 NZ_CP068819:1117464-1117799 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCCGG
ACATCGTCCGGCTGTTGTCCTGAGTCCGTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACGGTTGCCCCAGAGGAATTACAGCTCATTAAAGCCAAAATTAA
CGTGCTGATTGGGTAG
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCCGG
ACATCGTCCGGCTGTTGTCCTGAGTCCGTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACGGTTGCCCCAGAGGAATTACAGCTCATTAAAGCCAAAATTAA
CGTGCTGATTGGGTAG
Antitoxin
Download Length: 84 a.a. Molecular weight: 9194.43 Da Isoelectric Point: 4.1683
>AT155891 WP_000121743.1 NZ_CP053047:c8969-8718 [Escherichia fergusonii]
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPKLYAYYRELAEDAELNAVADERMKNPEIVKVNL
DDL
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPKLYAYYRELAEDAELNAVADERMKNPEIVKVNL
DDL
Download Length: 252 bp
>AT155891 NZ_CP068819:1117216-1117464 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | G3CAN5 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A3S5I301 |