Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3333188..3333807 Replicon chromosome
Accession NZ_CP053045
Organism Escherichia fergusonii strain HNCF11W

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag HG538_RS16105 Protein ID WP_001280991.1
Coordinates 3333589..3333807 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID B7LLQ9
Locus tag HG538_RS16100 Protein ID WP_000344803.1
Coordinates 3333188..3333562 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HG538_RS16090 3328320..3329513 + 1194 WP_002431407.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
HG538_RS16095 3329536..3332685 + 3150 WP_001132493.1 multidrug efflux RND transporter permease subunit -
HG538_RS16100 3333188..3333562 + 375 WP_000344803.1 Hha toxicity modulator TomB Antitoxin
HG538_RS16105 3333589..3333807 + 219 WP_001280991.1 hemolysin expression modulator Hha Toxin
HG538_RS16110 3334304..3334774 + 471 WP_002431406.1 YlaC family protein -
HG538_RS16115 3334913..3336463 + 1551 WP_001260375.1 EAL domain-containing protein -
HG538_RS16120 3336505..3336858 - 354 WP_000878140.1 DUF1428 domain-containing protein -
HG538_RS16130 3337237..3337548 + 312 WP_000409907.1 MGMT family protein -
HG538_RS16135 3337579..3338151 - 573 WP_171882114.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T155880 WP_001280991.1 NZ_CP053045:3333589-3333807 [Escherichia fergusonii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T155880 NZ_CP053045:3333589-3333807 [Escherichia fergusonii]
ATGTCCGATAAGCCTTTAACCAAAACTGATTATTTGATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAACGTGT
CATCGAAAAAAATAAATACGAACTCTCTGACAATGAACTGGCGGTATTTTATTCAGCAGCTGATCACCGTCTCGCTGAAT
TGACCATGAATAAACTTTACGACAAGATCCCCTCCTCCGTATGGAAATTCATTCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14525.33 Da        Isoelectric Point: 4.8989

>AT155880 WP_000344803.1 NZ_CP053045:3333188-3333562 [Escherichia fergusonii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT155880 NZ_CP053045:3333188-3333562 [Escherichia fergusonii]
ATGGACGAATACTCACCAAAACGACATGATATCGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAATCTTGAAGAGAGCAACCATGGCTGGGTTAACGACCCAACCTCGGCTATCAATCTGCAGCTCAACGAACTGATTGAGC
ATATTGCAACCTTCGCACTTAATTACAAAATTAAGTATAATGAGGACAATAAGCTCATAGAGCAGATCGATGAATATCTG
GATGACACTTTTATGTTGTTCAGTAGTTATGGCATTAATACACAGGATTTACAGAAATGGCGAAAATCTGGAAACAGGCT
CTTCCGCTGTTTTGTTAACGCCACCAGGGCGAACCCTGTTAGTTTGTCGTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A7K4HRV1

References