Detailed information of TA system TA155862

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 515065..515587
• Replicon: chromosome
• Accession: NZ_CP053045
• Organism: Escherichia fergusonii strain HNCF11W

Toxin (Protein)

• Gene name: relE
• Uniprot ID: F0JQI6
• Locus tag: HG538_RS02395
• Protein ID: WP_001105434.1
• Coordinates: 515297..515587 (+)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: F0JQI5
• Locus tag: HG538_RS02390
• Protein ID: WP_000212719.1
• Coordinates: 515065..515307 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HG538_RS02370	510982..512355	+	1374	WP_001219809.1	UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase	-
HG538_RS02375	512438..512989	-	552	WP_000166270.1	ribosome-associated protein	-
HG538_RS02380	513083..514435	+	1353	WP_001162171.1	metalloprotease PmbA	-
HG538_RS02385	514488..514874	+	387	WP_001232246.1	cytochrome b562	-
HG538_RS02390	515065..515307	+	243	WP_000212719.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
HG538_RS02395	515297..515587	+	291	WP_001105434.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HG538_RS02400	515588..516052	-	465	WP_001106232.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
HG538_RS02405	516237..518375	-	2139	WP_000187805.1	anaerobic ribonucleoside-triphosphate reductase	-
HG538_RS02410	518769..520424	-	1656	WP_000183356.1	alpha,alpha-phosphotrehalase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-82)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-65)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11323.22 Da
• Isoelectric Point: 10.3007

>T155862 WP_001105434.1 NZ_CP053045:515297-515587 [Escherichia fergusonii]
MNYELAFDPRALKEWQKLGVTVREQFKKKLGDVLKRPRNPSAKLRDLPDCYKIKLRTLGYRRVYQVNDKELIVLVIAIGK
RENSAVYEDATKRLDE

Nucleotide

• Length: 291 bp

>T155862 NZ_CP068818:956793-957200 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCCTGTTGATGGACGGGCGTTTGCGCTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9124.62 Da
• Isoelectric Point: 8.5314

>AT155862 WP_000212719.1 NZ_CP053045:515065-515307 [Escherichia fergusonii]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAENGRMPVKTLTVSDSEEALLRTVRKRLANPQEAIKVRLDEL

Nucleotide

• Length: 243 bp

>AT155862 NZ_CP068818:956546-956812 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGATGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Toxin

• AlphaFold DB: F0JQI6

Antitoxin

• AlphaFold DB: F0JQI5