Detailed information of TA system TA155861

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/GNAT-DUF1778
• Location: 1470709..1471454
• Replicon: chromosome
• Accession: NZ_CP053044
• Organism: Proteus terrae subsp. cibarius strain HNCF43W

Toxin (Protein)

• Gene name: tacT
• Uniprot ID: -
• Locus tag: HG541_RS06525
• Protein ID: WP_159241970.1
• Coordinates: 1470709..1471200 (-)
• Length: 164 a.a.

Antitoxin (Protein)

• Gene name: tacA
• Uniprot ID: -
• Locus tag: HG541_RS06530
• Protein ID: WP_075673024.1
• Coordinates: 1471188..1471454 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HG541_RS06505	1465794..1466900	+	1107	WP_159241966.1	flagellar basal body P-ring protein FlgI	-
HG541_RS06510	1466900..1467886	+	987	WP_159241967.1	flagellar assembly peptidoglycan hydrolase FlgJ	-
HG541_RS06515	1468004..1469647	+	1644	WP_159241968.1	flagellar hook-associated protein FlgK	-
HG541_RS06520	1469679..1470623	+	945	WP_159241969.1	flagellar hook-associated protein FlgL	-
HG541_RS06525	1470709..1471200	-	492	WP_159241970.1	GNAT family N-acetyltransferase	Toxin
HG541_RS06530	1471188..1471454	-	267	WP_075673024.1	DUF1778 domain-containing protein	Antitoxin
HG541_RS06535	1471578..1472360	-	783	WP_099660619.1	flagellar type III secretion system protein FliR	-
HG541_RS06540	1472366..1472635	-	270	WP_069367481.1	flagellar biosynthesis protein FliQ	-
HG541_RS06545	1472651..1473364	-	714	WP_171455369.1	flagellar type III secretion system pore protein FliP	-
HG541_RS06550	1473421..1473867	-	447	WP_075673022.1	flagellar biosynthetic protein FliO	-
HG541_RS06555	1473871..1474281	-	411	WP_006533153.1	flagellar motor switch protein FliN	-
HG541_RS06560	1474274..1475305	-	1032	WP_023581831.1	flagellar motor switch protein FliM	-
HG541_RS06565	1475311..1475793	-	483	WP_006533151.1	flagellar basal body-associated protein FliL	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (22-148)

Antitoxin

• Vibrio phage ICP1, Orf50 (2-87)

Sequences

Toxin

Protein

• Length: 164 a.a.
• Molecular weight: 18240.21 Da
• Isoelectric Point: 10.3194

>T155861 WP_159241970.1 NZ_CP053044:c1471200-1470709 [Proteus terrae subsp. cibarius]
MGKVTAPEPLSNSHEVADFYSSENVLDNWIKQRGLKNQFLGASRTFVVCEKNKKRVVGYYSLATGSVNHTEAMSHIRRNM
PDPIPVIILARLAVDKTFHGKGLGADLLRDAVLRCHHVAENIGVRAIMVHALTENAKHFYLHHGFKASSIQDKILFLALK
KKI

Nucleotide

• Length: 492 bp

>T155861 NZ_CP068818:c673920-673456 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTACAGCGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAGACAGAAGAAGCCCATTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10111.62 Da
• Isoelectric Point: 4.5256

>AT155861 WP_075673024.1 NZ_CP053044:c1471454-1471188 [Proteus terrae subsp. cibarius]
MKADVQLNIRAKESQRALIDTAAEILHKSRTDFILETACQAAEDVILDRRTFNLNDAQYAEFIEIIDAPVDIDPALEKLL
MRKPLWEK

Nucleotide

• Length: 267 bp

>AT155861 NZ_CP068818:c674255-673920 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCGACACTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA