Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 2495664..2497405 Replicon chromosome
Accession NZ_CP053042
Organism Proteus terrae subsp. cibarius strain HNCF44W

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag HG539_RS11480 Protein ID WP_098941872.1
Coordinates 2496032..2497405 (-) Length 458 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag HG539_RS11475 Protein ID WP_159241810.1
Coordinates 2495664..2496035 (-) Length 124 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HG539_RS11450 2491557..2493290 + 1734 WP_075673441.1 hydrogenase large subunit -
HG539_RS11455 2493302..2493856 + 555 WP_075673442.1 hydrogenase 4 subunit H -
HG539_RS11460 2493853..2494635 + 783 WP_072069032.1 NADH-quinone oxidoreductase subunit B family protein -
HG539_RS11465 2494628..2495038 + 411 WP_088494545.1 formate hydrogenlyase maturation HycH family protein -
HG539_RS11470 2495035..2495535 + 501 WP_075673444.1 hydrogenase maturation peptidase HycI -
HG539_RS11475 2495664..2496035 - 372 WP_159241810.1 helix-turn-helix domain-containing protein Antitoxin
HG539_RS11480 2496032..2497405 - 1374 WP_098941872.1 type II toxin-antitoxin system HipA family toxin Toxin
HG539_RS11485 2497787..2498776 + 990 WP_159241809.1 glycosyltransferase -
HG539_RS11490 2499182..2500765 + 1584 WP_099659717.1 ABC transporter substrate-binding protein -
HG539_RS11495 2500750..2501733 + 984 WP_075673449.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(174-418)

Antitoxin

Cro/C1-type helix-turn-helix domain

(48-103)


Sequences

Toxin        


Download         Length: 458 a.a.        Molecular weight: 52589.44 Da        Isoelectric Point: 4.6415

>T155854 WP_098941872.1 NZ_CP053042:c2497405-2496032 [Proteus terrae subsp. cibarius]
MEKITLQAFLNQEWVDIAIINFPKYDRMLYASKYDITYPITELEYETSYSIEHLYQDDQHAVSINHPVELYFDDSGSPGW
LKFLDDIVPSGASRRYWLQYLDIAELSTEQQNYELLHHGTISPIGNLRVKESLPAPSPLNRNLFFTINDVKNRASDFLDY
AQRKGAAAGGATGAGGEAPKLLLRCNDNEEVWIDTYQDDISNLDKYYLVKFPRGSRSVVDCNILRTEYHFYHELTDMGFD
TIPIKDMRLEEGDNYPSLWLPRFDIKIENNKIIRLAMESVYSILNKAPGTTLYHETVIKELIDKINQSNMVTEFGFQFNT
ANFIIEWVRRDLLNIIFGNSDNHGRNTSLIRYNNAIYLAPIYDFAPMKADPEGIARTTKWGSHSEIGGEYNFINIADSLS
DLIAPEQLLNALQETAQQLLTLKERLEMRGVPTQILTMPSFGFDFIPNKLERWGLLP

Download         Length: 1374 bp

>T155854 NZ_CP068817:c4705130-4704957 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTTCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 124 a.a.        Molecular weight: 13856.12 Da        Isoelectric Point: 10.6462

>AT155854 WP_159241810.1 NZ_CP053042:c2496035-2495664 [Proteus terrae subsp. cibarius]
MNNVENKNHIDKFPTRASRKHQFVATTDRKQVISKIMAHLLFGEITQGEALKMLRIKVLGLNQDLYAKLINVSRKTLSEI
ENDRGNYSADIINKVFKPFGLKVGLVPSSPHILSSLLKESPSN

Download         Length: 372 bp

>AT155854 NZ_CP068817:c4705454-4705158 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAACTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAGCATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References