Detailed information of TA system TA155852

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-MqsA
• Location: 2183118..2183817
• Replicon: chromosome
• Accession: NZ_CP053042
• Organism: Proteus terrae subsp. cibarius strain HNCF44W

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HG539_RS10115
• Protein ID: WP_075671320.1
• Coordinates: 2183431..2183817 (-)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: HG539_RS10110
• Protein ID: WP_075671318.1
• Coordinates: 2183118..2183438 (-)
• Length: 107 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HG539_RS10085	2179337..2179612	-	276	WP_004246820.1	DNA-directed RNA polymerase subunit omega	-
HG539_RS10090	2179667..2180290	-	624	WP_006534608.1	guanylate kinase	-
HG539_RS10095	2180596..2181213	-	618	WP_006534609.1	trimeric intracellular cation channel family protein	-
HG539_RS10100	2181350..2182636	+	1287	WP_159242125.1	DUF3748 domain-containing protein	-
HG539_RS10105	2182730..2183050	+	321	WP_075671316.1	hypothetical protein	-
HG539_RS10110	2183118..2183438	-	321	WP_075671318.1	helix-turn-helix domain-containing protein	Antitoxin
HG539_RS10115	2183431..2183817	-	387	WP_075671320.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HG539_RS10120	2183969..2186041	-	2073	WP_075671322.1	glycine--tRNA ligase subunit beta	-
HG539_RS10125	2186051..2186956	-	906	WP_004246832.1	glycine--tRNA ligase subunit alpha	-
HG539_RS10130	2187195..2187779	+	585	WP_159242124.1	DNA-3-methyladenine glycosylase I	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (1-125)

Antitoxin

• Cro/C1-type helix-turn-helix domain (50-96)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 14358.75 Da
• Isoelectric Point: 10.0463

>T155852 WP_075671320.1 NZ_CP053042:c2183817-2183431 [Proteus terrae subsp. cibarius]
MVIYKTKMFKNSFKKMPINDAALIDIANEVYAGHFEADLGGGIIKKRICIHGKGKSSGIRTIIFYKQGSNLFFADGWKKS
HLSAKKSKEITDDELESYKDLAKDLFSATKNKIDKMVALGLLTEVKHD

Nucleotide

• Length: 387 bp

>T155852 NZ_CP068817:4397147-4397488 [Escherichia coli]
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGCTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACTGCGGTAGATGTCAAAGTAATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGCCGAGAGCGAA
CTGATGCAGTCGCTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAGGCAGGTGCAGGAGTTTATTGGGGTGATTGC
GGGTAAACAGAAAGTCGCCTGA

Antitoxin

Protein

• Length: 107 a.a.
• Molecular weight: 12068.99 Da
• Isoelectric Point: 10.0482

>AT155852 WP_075671318.1 NZ_CP053042:c2183438-2183118 [Proteus terrae subsp. cibarius]
MTDKMQEMLKFAQEMEVAGITDGESARRIAARIKAKELKERYAHLTPMNGEDIKRIREQNNISQSSLALILNMTKESVSK
WERNEIKPNGAALRLLNLIDNKAISI

Nucleotide

• Length: 321 bp

>AT155852 NZ_CP068817:c4397152-4397076 [Escherichia coli]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT