Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
| Location | 203905..204650 | Replicon | plasmid pP35A |
| Accession | NZ_CP053036 | ||
| Organism | Klebsiella pneumoniae strain P35 | ||
Toxin (Protein)
| Gene name | tacT | Uniprot ID | A0A331KSM6 |
| Locus tag | HKJ75_RS26465 | Protein ID | WP_032408901.1 |
| Coordinates | 204159..204650 (+) | Length | 164 a.a. |
Antitoxin (Protein)
| Gene name | tacA | Uniprot ID | - |
| Locus tag | HKJ75_RS26460 | Protein ID | WP_014386183.1 |
| Coordinates | 203905..204171 (+) | Length | 89 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HKJ75_RS26410 | 199457..199870 | - | 414 | WP_013023817.1 | helix-turn-helix domain-containing protein | - |
| HKJ75_RS26415 | 199871..200149 | - | 279 | WP_004152721.1 | helix-turn-helix domain-containing protein | - |
| HKJ75_RS26420 | 200139..200459 | - | 321 | WP_014386190.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| HKJ75_RS26425 | 200540..200764 | - | 225 | WP_014386189.1 | hypothetical protein | - |
| HKJ75_RS26430 | 200775..200987 | - | 213 | WP_014386188.1 | hypothetical protein | - |
| HKJ75_RS26435 | 201049..201375 | - | 327 | WP_014386187.1 | hypothetical protein | - |
| HKJ75_RS26440 | 202012..202362 | - | 351 | WP_014386186.1 | hypothetical protein | - |
| HKJ75_RS26445 | 202359..202631 | - | 273 | WP_032408902.1 | hypothetical protein | - |
| HKJ75_RS26450 | 202821..203306 | + | 486 | WP_014386185.1 | hypothetical protein | - |
| HKJ75_RS26455 | 203550..203708 | - | 159 | WP_014386184.1 | type I toxin-antitoxin system Hok family toxin | - |
| HKJ75_RS26460 | 203905..204171 | + | 267 | WP_014386183.1 | DUF1778 domain-containing protein | Antitoxin |
| HKJ75_RS26465 | 204159..204650 | + | 492 | WP_032408901.1 | GNAT family N-acetyltransferase | Toxin |
| HKJ75_RS26470 | 205091..205342 | - | 252 | WP_032408900.1 | aldo/keto reductase | - |
| HKJ75_RS26475 | 205539..207131 | - | 1593 | Protein_219 | IS66 family transposase | - |
| HKJ75_RS26480 | 207162..207512 | - | 351 | WP_014386180.1 | IS66 family insertion sequence element accessory protein TnpB | - |
| HKJ75_RS26485 | 207509..207949 | - | 441 | WP_014386179.1 | IS66 family insertion sequence hypothetical protein | - |
| HKJ75_RS26490 | 208211..208966 | - | 756 | WP_032408898.1 | DeoR/GlpR family DNA-binding transcription regulator | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | mph(A) / sul1 / qacE / aadA2 / dfrA12 / catA1 | - | 1..248660 | 248660 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 164 a.a. Molecular weight: 17667.46 Da Isoelectric Point: 8.8757
>T155849 WP_032408901.1 NZ_CP053036:204159-204650 [Klebsiella pneumoniae]
VGKVTAPVPLGTSHILAEFHCGEPVLDEWIKHRGLKNQSLGAARTFVVCRGNASQVLAYYSLATGSVTHAIAPGSLRRNM
PDPVPVIILARLAVDTSYHGQGLGADLLHDAVLRCCRVAENIGVRAVMVHALSDSARQFYIHHGFIPSQTQDRTLFLRLP
LIT
VGKVTAPVPLGTSHILAEFHCGEPVLDEWIKHRGLKNQSLGAARTFVVCRGNASQVLAYYSLATGSVTHAIAPGSLRRNM
PDPVPVIILARLAVDTSYHGQGLGADLLHDAVLRCCRVAENIGVRAVMVHALSDSARQFYIHHGFIPSQTQDRTLFLRLP
LIT
Download Length: 492 bp
>T155849 NZ_CP068817:c3985745-3985347 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGAAGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGTGATGCACTCTACGACGACTCGTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGCAGCGCATTTGGTATATTGTCAGGGCGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGAAGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGTGATGCACTCTACGACGACTCGTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGCAGCGCATTTGGTATATTGTCAGGGCGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA
Antitoxin
Download Length: 89 a.a. Molecular weight: 10090.66 Da Isoelectric Point: 5.1169
>AT155849 WP_014386183.1 NZ_CP053036:203905-204171 [Klebsiella pneumoniae]
MKSDVQLNIRAKEAQRALIDTAAEILHKSRTDFILEMACQAAENVILDRRMFNLNDEQYAEFIDMLDAPVTANPAMEKLL
ARKPQWAK
MKSDVQLNIRAKEAQRALIDTAAEILHKSRTDFILEMACQAAENVILDRRMFNLNDEQYAEFIDMLDAPVTANPAMEKLL
ARKPQWAK
Download Length: 267 bp
>AT155849 NZ_CP068817:c3986041-3985748 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
TGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTTGAAGCATTAATGGACATGCTTG
CAGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCGAGTGCTGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
TGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTTGAAGCATTAATGGACATGCTTG
CAGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCGAGTGCTGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|