Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3987217..3987836 Replicon chromosome
Accession NZ_CP053035
Organism Klebsiella pneumoniae strain P35

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag HKJ75_RS19375 Protein ID WP_002892050.1
Coordinates 3987618..3987836 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag HKJ75_RS19370 Protein ID WP_002892066.1
Coordinates 3987217..3987591 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HKJ75_RS19360 3982369..3983562 + 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
HKJ75_RS19365 3983585..3986731 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
HKJ75_RS19370 3987217..3987591 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
HKJ75_RS19375 3987618..3987836 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
HKJ75_RS19380 3987995..3988561 + 567 WP_002892030.1 maltose O-acetyltransferase -
HKJ75_RS19385 3988533..3988673 - 141 WP_004147370.1 hypothetical protein -
HKJ75_RS19390 3988694..3989164 + 471 WP_002892026.1 YlaC family protein -
HKJ75_RS19395 3989139..3990590 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
HKJ75_RS19400 3990691..3991389 + 699 WP_002892021.1 GNAT family N-acetyltransferase -
HKJ75_RS19405 3991386..3991526 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
HKJ75_RS19410 3991526..3991789 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T155843 WP_002892050.1 NZ_CP053035:3987618-3987836 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T155843 NZ_CP068817:2852114-2852221 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT155843 WP_002892066.1 NZ_CP053035:3987217-3987591 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT155843 NZ_CP068817:c2852061-2852000 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References