Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 834943..835600 Replicon chromosome
Accession NZ_CP053035
Organism Klebsiella pneumoniae strain P35

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag HKJ75_RS04120 Protein ID WP_002916310.1
Coordinates 835190..835600 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag HKJ75_RS04115 Protein ID WP_002916312.1
Coordinates 834943..835209 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HKJ75_RS04090 830099..831532 - 1434 WP_020324925.1 6-phospho-beta-glucosidase -
HKJ75_RS04095 831651..832379 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
HKJ75_RS04100 832429..832740 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
HKJ75_RS04105 832904..833563 + 660 WP_002916317.1 hemolysin III family protein -
HKJ75_RS04110 833714..834697 - 984 WP_020324927.1 tRNA-modifying protein YgfZ -
HKJ75_RS04115 834943..835209 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
HKJ75_RS04120 835190..835600 + 411 WP_002916310.1 protein YgfX Toxin
HKJ75_RS04125 835607..836128 - 522 WP_004144730.1 flavodoxin FldB -
HKJ75_RS04130 836229..837125 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
HKJ75_RS04135 837148..837861 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HKJ75_RS04140 837867..839600 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T155832 WP_002916310.1 NZ_CP053035:835190-835600 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T155832 NZ_CP068817:188778-188885 [Escherichia coli]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAATAAGCGGAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT155832 WP_002916312.1 NZ_CP053035:834943-835209 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT155832 NZ_CP068817:c188729-188663 [Escherichia coli]
GTCTAGGTTCAAGATTAGCCCCCGTGATATTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References