Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/DUF433(antitoxin)
Location 3832285..3832847 Replicon chromosome
Accession NZ_CP053032
Organism Halomonas sp. PGE1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag HIR79_RS17905 Protein ID WP_169959382.1
Coordinates 3832285..3832626 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag HIR79_RS17910 Protein ID WP_169959383.1
Coordinates 3832623..3832847 (-) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HIR79_RS17885 3827532..3828572 - 1041 WP_169957516.1 IS110 family transposase -
HIR79_RS17890 3828749..3830272 - 1524 WP_169959652.1 murein biosynthesis integral membrane protein MurJ -
HIR79_RS17895 3830642..3830908 - 267 WP_119022583.1 30S ribosomal protein S20 -
HIR79_RS17900 3831117..3832256 - 1140 WP_169959381.1 glutamate 5-kinase -
HIR79_RS17905 3832285..3832626 - 342 WP_169959382.1 DUF5615 family PIN-like protein Toxin
HIR79_RS17910 3832623..3832847 - 225 WP_169959383.1 DUF433 domain-containing protein Antitoxin
HIR79_RS17915 3832892..3834079 - 1188 WP_169959384.1 Obg family GTPase CgtA -
HIR79_RS17920 3834180..3834437 - 258 WP_110070533.1 50S ribosomal protein L27 -
HIR79_RS17925 3834469..3834780 - 312 WP_169959385.1 50S ribosomal protein L21 -
HIR79_RS17930 3835064..3836059 + 996 WP_169959386.1 octaprenyl diphosphate synthase -
HIR79_RS17940 3836365..3836817 - 453 WP_169959387.1 universal stress protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3812377..3842501 30124


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Domain of unknown function DUF5615

(1-78)

Antitoxin

Protein of unknown function DUF433

(8-63)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12726.59 Da        Isoelectric Point: 4.5141

>T155829 WP_169959382.1 NZ_CP053032:c3832626-3832285 [Halomonas sp. PGE1]
MILWVDAQLSPHLAPWMTDTLGVEAYSARWLGYRDATDEDIFAAARDAGAIVLTKDRDFPDLLERYGPPPKVIWVTMGNT
TNARMREVLQRLLPTALELLAKGESLVELSDRQ

Download         Length: 342 bp

>T155829 NZ_CP068816:c4380620-4380243 [Escherichia coli]
ATGAACACATTACCCGATACACACATACGGGAGGCATCGCATTGCCAGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACTCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGGCCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8120.46 Da        Isoelectric Point: 4.4454

>AT155829 WP_169959383.1 NZ_CP053032:c3832847-3832623 [Halomonas sp. PGE1]
MNALLSRITIDPAQCGGRPCIRGMRIRVVDVLDLLAQGLTAQEVLEELPDLEQEDILASLQFAARRLDHPVLAA

Download         Length: 225 bp

>AT155829 NZ_CP068816:c4381078-4380710 [Escherichia coli]
GTGTCAGACACTCTCCCCGGGACAACGCATCCCGACGATAACAACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTTGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAAGGCTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGCTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References