Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YoeB-YefM
Location 2588868..2589373 Replicon chromosome
Accession NZ_CP053032
Organism Halomonas sp. PGE1

Toxin (Protein)


Gene name relB Uniprot ID -
Locus tag HIR79_RS12230 Protein ID WP_169958574.1
Coordinates 2588868..2589122 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name relE Uniprot ID -
Locus tag HIR79_RS12235 Protein ID WP_169958575.1
Coordinates 2589119..2589373 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HIR79_RS12215 2584074..2584754 - 681 Protein_2401 MATE family efflux transporter -
HIR79_RS12220 2585569..2586324 - 756 WP_169958573.1 universal stress protein -
HIR79_RS12225 2586317..2588749 - 2433 WP_169959572.1 ATP-binding protein -
HIR79_RS12230 2588868..2589122 - 255 WP_169958574.1 Txe/YoeB family addiction module toxin Toxin
HIR79_RS12235 2589119..2589373 - 255 WP_169958575.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
HIR79_RS12240 2589491..2590711 - 1221 WP_169958576.1 transposase -
HIR79_RS12245 2590896..2591327 - 432 WP_169958577.1 low molecular weight phosphotyrosine protein phosphatase -
HIR79_RS12250 2591339..2592781 - 1443 WP_169958578.1 MBL fold metallo-hydrolase -
HIR79_RS12255 2593110..2593256 + 147 WP_169958579.1 hypothetical protein -
HIR79_RS12260 2593367..2593792 + 426 WP_169958580.1 nucleotidyltransferase domain-containing protein -
HIR79_RS12265 2593782..2594003 + 222 WP_169958581.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2589491..2590711 1220


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10296.79 Da        Isoelectric Point: 9.6938

>T155826 WP_169958574.1 NZ_CP053032:c2589122-2588868 [Halomonas sp. PGE1]
MMLTWATPAWEDYLYWQGRDKKTLKRINTLIKDIQRQPFDGLGDPEPLRHQWSGYWSRRVDREHRLVYKVTDSAIVIVQC
RYHY

Download         Length: 255 bp

>T155826 NZ_CP068816:c4180249-4179935 [Escherichia coli]
ATGCAATTTACGGTATACCGCAGTCGCGGCAGGAACGCCGCGTTTCCCTTTGTTATTGATGTTACCAGCGACATTATTGG
TGAGATTAATCGCCGTATCGTTATTCCATTAACACCTATTGAACGATTTAGCCGTATTCGCCCACCAGAACGGCTTAACC
CAATCCTTTTACTGGTAGACGGCAAAGAATATGTGCTCATGACGCATGAGACTGCAACTGTTCCAGTTAACGCGCTGGGA
ACGAAATTTTGCGATGCCAGCGCGCACCGAACGTTGATTAAAGGAGCATTAGATTTTATGCTCGACGGGATTTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9438.50 Da        Isoelectric Point: 4.6216

>AT155826 WP_169958575.1 NZ_CP053032:c2589373-2589119 [Halomonas sp. PGE1]
MDTVTYTHFRSHLAQVLDRVNDDHVPVLITRQNGKPAIVMSVEDFKSYEETAYLMASPENARRLNDAIAEVERGEGGEHG
LIDP

Download         Length: 255 bp

>AT155826 NZ_CP068816:c4180485-4180252 [Escherichia coli]
ATGACTGCAAAACGTACCACACAAAGTGTGACCGTCACCGTCGACCGTGAGTTAGTCAATCGCGCTCGTGATGCAGGCTT
AAATATGAGCGCCACCCTTACGGTTGCGCTCAATGCTGAACTTAAAAAACATGCAGCAACACGTTGGCGTGAAGAGAACA
CAGAAGCTATCGCTGCGTTAAATCAATTGGCTGATGAAACCGGATGTTTCTCTGATGAGTACCGGAGCTTCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References