Detailed information of TA system TA155824

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 2480854..2481376
• Replicon: chromosome
• Accession: NZ_CP053032
• Organism: Halomonas sp. PGE1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HIR79_RS11705
• Protein ID: WP_110070305.1
• Coordinates: 2481092..2481376 (+)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: HIR79_RS11700
• Protein ID: WP_110070304.1
• Coordinates: 2480854..2481102 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HIR79_RS11680	2476268..2477413	+	1146	WP_169959560.1	IS110 family transposase	-
HIR79_RS11685	2477930..2478232	-	303	WP_119023085.1	DNA helicase	-
HIR79_RS11690	2478247..2479923	-	1677	WP_169958495.1	carbon starvation protein A	-
HIR79_RS11695	2480170..2480799	+	630	WP_169958496.1	dephospho-CoA kinase	-
HIR79_RS11700	2480854..2481102	+	249	WP_110070304.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
HIR79_RS11705	2481092..2481376	+	285	WP_110070305.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HIR79_RS11710	2481391..2481624	+	234	WP_169958497.1	DNA gyrase inhibitor YacG	-
HIR79_RS11715	2481626..2481817	+	192	WP_110070307.1	DUF2283 domain-containing protein	-
HIR79_RS11720	2481834..2482712	+	879	WP_169958498.1	DNA replication terminus site-binding protein	-
HIR79_RS11725	2483061..2483246	-	186	WP_110070309.1	hypothetical protein	-
HIR79_RS11730	2483356..2483766	-	411	WP_169958499.1	SRPBCC family protein	-
HIR79_RS11735	2483792..2484145	-	354	WP_169958500.1	type II toxin-antitoxin system PemK/MazF family toxin	-
HIR79_RS11740	2484142..2484381	-	240	WP_169958501.1	DUF2281 domain-containing protein	-
HIR79_RS11745	2484602..2485927	+	1326	WP_169958502.1	30S ribosomal protein S12 methylthiotransferase RimO	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	bplB	2477930..2577843	99913

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-84)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11145.05 Da
• Isoelectric Point: 11.0523

>T155824 WP_110070305.1 NZ_CP053032:2481092-2481376 [Halomonas sp. PGE1]
MTYELRFRKEALKEWRKLDGSVRAQFKKKLTAILDSPSIPAARLHGNRDRYKIKLRSAGYRLVYEVRNNELVVVVIAIGK
RERNDVYMKADKRH

Nucleotide

• Length: 285 bp

>T155824 NZ_CP068816:c3861971-3861594 [Escherichia coli]
ATGAAAACATTACCCGACACACACGTACGGGAGGCATCGCGCTGCCTGTCTCCGGTTGAAATCTGGCAGACACTGCTCAC
CCGGTTACTGGACCAGCACTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AAGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCCCTGGTGCGTACCGACCAGCCGGGATTC
AGCCCCTGTACCCGCTCTCAGTTAATCAACAGTATCGATATCCTCCGGGCACGCCGGGCAACCGGCCTGATGACCCGCGA
TAACTACAGAACGGTAAATAACATTACCCGGGGTAAGCATCCGGAGGCGAAACAATGA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 8927.08 Da
• Isoelectric Point: 4.0742

>AT155824 WP_110070304.1 NZ_CP053032:2480854-2481102 [Halomonas sp. PGE1]
MPHTILANTTASISELKKNPMATVAAGEGFPVAVLNRNEPAFYCIPAAAYEELLEKLEDAELNRIADERSQQPEIAVSLD
DL

Nucleotide

• Length: 249 bp

>AT155824 NZ_CP068816:c3862429-3862061 [Escherichia coli]
GTGTCAGACGCACTCTCCGGGACAATGCTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACAGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGTCTGACCTGCAAAGCTGACACTCTCGGTAGCGG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA