Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 1365875..1366437 Replicon chromosome
Accession NZ_CP053032
Organism Halomonas sp. PGE1

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag HIR79_RS06435 Protein ID WP_169957700.1
Coordinates 1365875..1366192 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID -
Locus tag HIR79_RS06440 Protein ID WP_169957701.1
Coordinates 1366192..1366437 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HIR79_RS06410 1361947..1363677 + 1731 WP_169957696.1 hypothetical protein -
HIR79_RS06415 1363737..1364003 + 267 WP_119023289.1 hypothetical protein -
HIR79_RS06420 1364091..1364495 + 405 WP_169957697.1 hypothetical protein -
HIR79_RS06425 1364488..1365384 + 897 WP_169957698.1 PhzF family phenazine biosynthesis protein -
HIR79_RS06430 1365381..1365845 + 465 WP_169957699.1 hypothetical protein -
HIR79_RS06435 1365875..1366192 - 318 WP_169957700.1 CcdB family protein Toxin
HIR79_RS06440 1366192..1366437 - 246 WP_169957701.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
HIR79_RS06445 1366508..1367086 - 579 WP_169957702.1 antibiotic biosynthesis monooxygenase -
HIR79_RS06450 1367331..1368206 - 876 WP_169957703.1 alpha/beta hydrolase -
HIR79_RS06455 1368453..1369862 + 1410 WP_169957704.1 CHAD domain-containing protein -
HIR79_RS06460 1369902..1370765 - 864 WP_169957705.1 SDR family oxidoreductase -
HIR79_RS06465 1370806..1371099 - 294 WP_119023280.1 DUF503 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1363674..1386991 23317


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(3-104)

Antitoxin

Post-segregation antitoxin CcdA

(11-81)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 11832.71 Da        Isoelectric Point: 8.0425

>T155823 WP_169957700.1 NZ_CP053032:c1366192-1365875 [Halomonas sp. PGE1]
MAQFHAYENRNPASRKRYPYLLDIQSNLLGELRTTVVVPLCPVGIAESLRISHLNPSIEIDGERYIALTQELAGMERKRL
GKAVHDLGLYRDRIIAAVDFLVTGI

Download         Length: 318 bp

>T155823 NZ_CP068816:3671925-3672143 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGTCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCTGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9254.11 Da        Isoelectric Point: 5.0807

>AT155823 WP_169957701.1 NZ_CP053032:c1366437-1366192 [Halomonas sp. PGE1]
MTQPYDTQAPKKATNVSINSDLLQQARRLGINLSATFESALSDKVRAEQRERWQRENTDAIRAYNQFAEENGTFGDGERT
F

Download         Length: 246 bp

>AT155823 NZ_CP068816:3671525-3671899 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References