155813

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 143567..144072 Replicon chromosome
Accession NZ_CP053028
Organism Pseudomonas aeruginosa PAO1

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag HKX07_RS00660 Protein ID WP_003083773.1
Coordinates 143567..143848 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q9I707
Locus tag HKX07_RS00665 Protein ID WP_003112628.1
Coordinates 143845..144072 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HKX07_RS00635 138818..140167 + 1350 WP_003142411.1 C4-dicarboxylate transporter DctA -
HKX07_RS00640 140216..140902 + 687 WP_003083762.1 FadR family transcriptional regulator -
HKX07_RS00645 141003..141737 + 735 WP_003115036.1 GntR family transcriptional regulator -
HKX07_RS00650 141941..142327 + 387 WP_014602345.1 aegerolysin family protein -
HKX07_RS00655 142359..143267 - 909 WP_003083769.1 LysR family transcriptional regulator -
HKX07_RS00660 143567..143848 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
HKX07_RS00665 143845..144072 - 228 WP_003112628.1 CopG family ribbon-helix-helix protein Antitoxin
HKX07_RS00670 144248..144868 - 621 WP_003101226.1 hypothetical protein -
HKX07_RS00675 144969..145469 + 501 WP_003112629.1 LEA type 2 family protein -
HKX07_RS00680 145542..145883 + 342 WP_003101229.1 alkylphosphonate utilization protein -
HKX07_RS00685 145965..147392 - 1428 WP_003083784.1 GABA permease -
HKX07_RS00690 147561..149054 - 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T155813 WP_003083773.1 NZ_CP053028:c143848-143567 [Pseudomonas aeruginosa PAO1]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T155813 NZ_CP068816:1949270-1949521 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8568.64 Da        Isoelectric Point: 5.5740

>AT155813 WP_003112628.1 NZ_CP053028:c144072-143845 [Pseudomonas aeruginosa PAO1]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHIEIEKRWGLQ

Download         Length: 228 bp

>AT155813 NZ_CP068816:1949518-1949772 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAAATTATCAAAGATACACGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GCTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB Q9I707

References