Detailed information of TA system TA155812

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelB(antitoxin)
• Location: 250893..251505
• Replicon: chromosome
• Accession: NZ_CP053027
• Organism: Streptococcus agalactiae strain 01173

Toxin (Protein)

• Gene name: parE
• Uniprot ID: A0A8G2N8L3
• Locus tag: HKK59_RS01445
• Protein ID: WP_000384860.1
• Coordinates: 250893..251228 (-)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: Q8E7D2
• Locus tag: HKK59_RS01450
• Protein ID: WP_000259017.1
• Coordinates: 251218..251505 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HKK59_RS01420	246091..246732	+	642	WP_000591144.1	hypothetical protein	-
HKK59_RS01425	247032..247907	+	876	WP_000421240.1	hypothetical protein	-
HKK59_RS01430	247943..248377	+	435	WP_001220479.1	hypothetical protein	-
HKK59_RS01435	248694..249950	+	1257	WP_000122836.1	plasmid recombination protein	-
HKK59_RS01440	250118..250588	+	471	WP_000130119.1	hypothetical protein	-
HKK59_RS01445	250893..251228	-	336	WP_000384860.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HKK59_RS01450	251218..251505	-	288	WP_000259017.1	hypothetical protein	Antitoxin
HKK59_RS01455	252012..252302	+	291	WP_000078283.1	WXG100 family type VII secretion target	-
HKK59_RS01460	252404..252811	+	408	WP_000749954.1	hypothetical protein	-
HKK59_RS01465	252811..253371	+	561	WP_001865562.1	hypothetical protein	-
HKK59_RS01470	253344..254024	+	681	WP_001865565.1	hypothetical protein	-
HKK59_RS01475	254009..254395	+	387	WP_000259069.1	hypothetical protein	-
HKK59_RS01480	254429..254710	+	282	WP_000052406.1	hypothetical protein	-
HKK59_RS01485	255553..256413	+	861	WP_000477654.1	Rgg/GadR/MutR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	242924..251779	8855

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-106)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 13227.87 Da
• Isoelectric Point: 4.5348

>T155812 WP_000384860.1 NZ_CP053027:c251228-250893 [Streptococcus agalactiae]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIINDIEKLEVFPEVGFDADEKYGSEISNYHSTRGYTLSKD
YIVLYHIEEEENSVVIDYLLPTRSDYMKLFK

Nucleotide

• Length: 336 bp

>T155812 NZ_CP068816:1129619-1129954 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATACGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCCGG
ACATCGTCCGGCTGTTGTCCTGAGTCCGTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTCTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGA
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTGCTGATTGGGTAG

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10906.50 Da
• Isoelectric Point: 4.7271

>AT155812 WP_000259017.1 NZ_CP053027:c251505-251218 [Streptococcus agalactiae]
MVTVEKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEISKNIEDVRQ
GKFYTSEEVRAELGL

Nucleotide

• Length: 288 bp

>AT155812 NZ_CP068816:1129371-1129619 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGGGAGCCGAAAGATAAGGAA
GTCTGGTAA

Structures

Antitoxin

• AlphaFold DB: A0A076Z4V6