Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relB-parE/ParE-RHH |
| Location | 29331..29890 | Replicon | plasmid p-C-Sy |
| Accession | NZ_CP053024 | ||
| Organism | Sphingobium yanoikuyae strain YC-XJ2 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | - |
| Locus tag | HH800_RS28765 | Protein ID | WP_169863574.1 |
| Coordinates | 29331..29624 (-) | Length | 98 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | A0A0J7XF30 |
| Locus tag | HH800_RS28770 | Protein ID | WP_059153569.1 |
| Coordinates | 29612..29890 (-) | Length | 93 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HH800_RS28705 | 24524..24838 | + | 315 | Protein_26 | hypothetical protein | - |
| HH800_RS28710 | 24867..25124 | - | 258 | Protein_27 | DUF2442 domain-containing protein | - |
| HH800_RS28715 | 25173..25349 | - | 177 | Protein_28 | cytoplasmic protein | - |
| HH800_RS28720 | 25374..25667 | - | 294 | WP_169863569.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| HH800_RS28725 | 25660..25938 | - | 279 | WP_159368254.1 | type II toxin-antitoxin system ParD family antitoxin | - |
| HH800_RS28730 | 26071..26199 | + | 129 | WP_169863570.1 | hypothetical protein | - |
| HH800_RS28735 | 26186..26416 | + | 231 | WP_169863571.1 | BrnA antitoxin family protein | - |
| HH800_RS28740 | 26448..26775 | + | 328 | Protein_33 | hypothetical protein | - |
| HH800_RS28745 | 26818..27210 | - | 393 | Protein_34 | IS66 family insertion sequence element accessory protein TnpB | - |
| HH800_RS28750 | 27112..28485 | + | 1374 | WP_169863572.1 | hypothetical protein | - |
| HH800_RS28755 | 28599..28778 | - | 180 | WP_169863561.1 | hypothetical protein | - |
| HH800_RS28760 | 28922..29203 | + | 282 | WP_169863573.1 | WGR domain-containing protein | - |
| HH800_RS28765 | 29331..29624 | - | 294 | WP_169863574.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| HH800_RS28770 | 29612..29890 | - | 279 | WP_059153569.1 | CopG family ribbon-helix-helix protein | Antitoxin |
| HH800_RS28775 | 30282..30842 | + | 561 | WP_169863596.1 | recombinase family protein | - |
| HH800_RS28780 | 30857..32194 | + | 1338 | WP_169863575.1 | phosphoglucosamine mutase | - |
| HH800_RS28785 | 32227..32535 | - | 309 | WP_169863576.1 | hypothetical protein | - |
| HH800_RS28790 | 32532..33788 | - | 1257 | WP_169863577.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | tviB | 1..57270 | 57270 | |
| - | flank | IS/Tn | - | - | 30282..30842 | 560 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 98 a.a. Molecular weight: 10970.48 Da Isoelectric Point: 7.4007
>T155811 WP_169863574.1 NZ_CP053024:c29624-29331 [Sphingobium yanoikuyae]
VPRLIWTAEALADVDRLHRWLKTKDADAVRRAVAAIRGGVRILAATPHIGRPTEDMESEYREKLIDFGNSGYVVLYHFDG
ETVALLAVRHQREAGYQ
VPRLIWTAEALADVDRLHRWLKTKDADAVRRAVAAIRGGVRILAATPHIGRPTEDMESEYREKLIDFGNSGYVVLYHFDG
ETVALLAVRHQREAGYQ
Download Length: 294 bp
>T155811 NZ_CP068816:974416-974823 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATTCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGAAAACGGCA
ACATTTATGGCTGGCAGCTGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTACAACAAGAGACGC
AAAGATAA
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATTCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGAAAACGGCA
ACATTTATGGCTGGCAGCTGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTACAACAAGAGACGC
AAAGATAA
Antitoxin
Download Length: 93 a.a. Molecular weight: 10613.95 Da Isoelectric Point: 6.4833
>AT155811 WP_059153569.1 NZ_CP053024:c29890-29612 [Sphingobium yanoikuyae]
MATATSIKLDDALKGRVQHLANARRRSSHWIMREAIAQYVEREEKREAFKQDAIRAWENYQQTGLHVTLEEADVWLAKLE
AGEDAEPPKCHV
MATATSIKLDDALKGRVQHLANARRRSSHWIMREAIAQYVEREEKREAFKQDAIRAWENYQQTGLHVTLEEADVWLAKLE
AGEDAEPPKCHV
Download Length: 279 bp
>AT155811 NZ_CP068816:974169-974435 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|