Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hipBA/HipA-couple_hipB |
| Location | 107327..108831 | Replicon | plasmid p-A-Sy |
| Accession | NZ_CP053022 | ||
| Organism | Sphingobium yanoikuyae strain YC-XJ2 | ||
Toxin (Protein)
| Gene name | HipA1 | Uniprot ID | A0A6M4GEY9 |
| Locus tag | HH800_RS25730 | Protein ID | WP_026109697.1 |
| Coordinates | 107557..108831 (+) | Length | 425 a.a. |
Antitoxin (Protein)
| Gene name | HipB1 | Uniprot ID | - |
| Locus tag | HH800_RS25725 | Protein ID | WP_017503541.1 |
| Coordinates | 107327..107560 (+) | Length | 78 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HH800_RS25710 | 102537..103106 | + | 570 | WP_026109580.1 | type 1 glutamine amidotransferase | - |
| HH800_RS25715 | 103363..105954 | - | 2592 | WP_037522566.1 | excinuclease ABC subunit UvrA | - |
| HH800_RS25720 | 106593..107213 | + | 621 | WP_017503542.1 | type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein | - |
| HH800_RS25725 | 107327..107560 | + | 234 | WP_017503541.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| HH800_RS25730 | 107557..108831 | + | 1275 | WP_026109697.1 | type II toxin-antitoxin system HipA family toxin | Toxin |
| HH800_RS25735 | 108908..109744 | - | 837 | WP_155276517.1 | hypothetical protein | - |
| HH800_RS25740 | 109836..110111 | - | 276 | Protein_94 | ATP-dependent Lon protease | - |
| HH800_RS25745 | 110230..111753 | + | 1524 | WP_169863454.1 | IS21 family transposase | - |
| HH800_RS25750 | 111743..112549 | + | 807 | WP_169863455.1 | IS21-like element helper ATPase IstB | - |
| HH800_RS25755 | 112609..112815 | - | 207 | Protein_97 | WYL domain-containing protein | - |
| HH800_RS25760 | 112958..113401 | - | 444 | Protein_98 | hypothetical protein | - |
| HH800_RS25765 | 113406..113711 | + | 306 | Protein_99 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..371560 | 371560 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 425 a.a. Molecular weight: 45042.76 Da Isoelectric Point: 6.5084
>T155809 WP_026109697.1 NZ_CP053022:107557-108831 [Sphingobium yanoikuyae]
VTADILERLVVWSDQRIAGELSIDRGGAMHFIYADDWLADPAAGPLSHALPKQAEPFGDALCKAVFGGLLPEEGQRTAIA
RALGVSPDNPFRLLAALGGDVAGALAFLPEGEKPPLPPEGELPPALDDAELAVLIGRLPRVPMLAGQGGARLSLAGAQGK
LPVVLAEGRVAVPRVGEPSTHLIKPEPDRFPGLAANEGFCLALARAVGLDAAMAEWREVADKPYLLVTRYDRLDRDGHTI
RLHQEDFAQAQGVPSNRKYASEGGPTFRDCFALARQATTRPAREVLKLADAAIFNVIIGNADAHAKNYSLVRQSKGEVVL
APLYDLVATHMWPELSAKLAMRFGRAATLEEINAGSFVRFAGDTGLALPFLRRRVAALAGRVREVISGGVTVPGLDGTAR
LGELPSIVLDRAARLALKAELHGN
VTADILERLVVWSDQRIAGELSIDRGGAMHFIYADDWLADPAAGPLSHALPKQAEPFGDALCKAVFGGLLPEEGQRTAIA
RALGVSPDNPFRLLAALGGDVAGALAFLPEGEKPPLPPEGELPPALDDAELAVLIGRLPRVPMLAGQGGARLSLAGAQGK
LPVVLAEGRVAVPRVGEPSTHLIKPEPDRFPGLAANEGFCLALARAVGLDAAMAEWREVADKPYLLVTRYDRLDRDGHTI
RLHQEDFAQAQGVPSNRKYASEGGPTFRDCFALARQATTRPAREVLKLADAAIFNVIIGNADAHAKNYSLVRQSKGEVVL
APLYDLVATHMWPELSAKLAMRFGRAATLEEINAGSFVRFAGDTGLALPFLRRRVAALAGRVREVISGGVTVPGLDGTAR
LGELPSIVLDRAARLALKAELHGN
Download Length: 1275 bp
>T155809 NZ_CP068816:c609042-608578 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGATGCTTTAGTTGC
CGAAGTCGAGGCATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCTGCCACAAAGTTATTGGCGGTGGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGCTATCGTCTCTTCTTTCGTTACAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGTAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAGCCATTGA
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGATGCTTTAGTTGC
CGAAGTCGAGGCATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCTGCCACAAAGTTATTGGCGGTGGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGCTATCGTCTCTTCTTTCGTTACAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGTAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAGCCATTGA
Antitoxin
Download Length: 78 a.a. Molecular weight: 8319.81 Da Isoelectric Point: 6.2620
>AT155809 WP_017503541.1 NZ_CP053022:107327-107560 [Sphingobium yanoikuyae]
MLDMTMIGQIVRDERKEMGLRQDELAAASGVGLRFIVELERGKATAQIGKVITVLAALGCELQIRRPDGIVIAGQPT
MLDMTMIGQIVRDERKEMGLRQDELAAASGVGLRFIVELERGKATAQIGKVITVLAALGCELQIRRPDGIVIAGQPT
Download Length: 234 bp
>AT155809 NZ_CP068816:c609377-609042 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTAACGCTGTACTGACCACTGAATCAAAGGTCACTATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCTGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCGACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGACGATGAGAT
TGGCGACGACGAATAA
ATGCCCGCTAATGCTCGCTCTAACGCTGTACTGACCACTGAATCAAAGGTCACTATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCTGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCGACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGACGATGAGAT
TGGCGACGACGAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|