155808

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) BrnTA/BrnT-BrnA
Location 47348..47877 Replicon plasmid p-A-Sy
Accession NZ_CP053022
Organism Sphingobium yanoikuyae strain YC-XJ2

Toxin (Protein)


Gene name brnT Uniprot ID A0A084E9V8
Locus tag HH800_RS25440 Protein ID WP_017502885.1
Coordinates 47348..47593 (+) Length 82 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID A0A084E9V9
Locus tag HH800_RS25445 Protein ID WP_017502886.1
Coordinates 47590..47877 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HH800_RS25415 42989..43999 - 1011 WP_017502880.1 FecR domain-containing protein -
HH800_RS25420 43968..44570 - 603 WP_017502881.1 sigma-70 family RNA polymerase sigma factor -
HH800_RS25425 45075..45749 - 675 WP_026109545.1 GNAT family N-acetyltransferase -
HH800_RS25430 45875..46402 + 528 WP_037522378.1 LysR family transcriptional regulator -
HH800_RS25435 46365..46775 - 411 WP_080727348.1 LysR family transcriptional regulator -
HH800_RS25440 47348..47593 + 246 WP_017502885.1 BrnT family toxin Toxin
HH800_RS25445 47590..47877 + 288 WP_017502886.1 BrnA antitoxin family protein Antitoxin
HH800_RS25450 47975..49198 - 1224 WP_037522360.1 Fic family protein -
HH800_RS25455 49278..49595 + 318 WP_080727349.1 hypothetical protein -
HH800_RS25460 49713..49808 - 96 Protein_38 S1/P1 Nuclease -
HH800_RS25465 49812..49904 - 93 Protein_39 IS5/IS1182 family transposase -
HH800_RS25470 50034..50237 + 204 WP_017502892.1 hypothetical protein -
HH800_RS25475 50556..51176 + 621 WP_162181991.1 hypothetical protein -
HH800_RS25480 51128..51316 + 189 WP_080727350.1 transposase -
HH800_RS25485 51431..52288 - 858 WP_017502894.1 ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..371560 371560


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(5-76)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(22-92)


Sequences

Toxin        


Download         Length: 82 a.a.        Molecular weight: 8754.27 Da        Isoelectric Point: 7.0106

>T155808 WP_017502885.1 NZ_CP053022:47348-47593 [Sphingobium yanoikuyae]
MIIVWDEPKRQANLVKHGIDFADVGEGFFLSALVMPAKDGRFAAIGEMNGKITVIFAVLGTEGVSIISARPASITERRLL
P

Download         Length: 246 bp

>T155808 NZ_CP068816:188778-188885 [Escherichia coli]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAATAAGCGGAAGTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10426.82 Da        Isoelectric Point: 9.9637

>AT155808 WP_017502886.1 NZ_CP053022:47590-47877 [Sphingobium yanoikuyae]
MTYPKNAALGYTKADMDAVSNNPEWTAEDFARAKPFAEAFPDLAKSIRARGPQKAPKKVSTTLRLSPEVIEHFKSGGPGW
QSRIDAALKDWVAAH

Download         Length: 288 bp

>AT155808 NZ_CP068816:c188729-188663 [Escherichia coli]
GTCTAGGTTCAAGATTAGCCCCCGTGATATTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A084E9V8

Antitoxin

Source ID Structure
AlphaFold DB A0A084E9V9

References