Detailed information of TA system TA155807

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 4842366..4843039
• Replicon: chromosome
• Accession: NZ_CP053021
• Organism: Sphingobium yanoikuyae strain YC-XJ2

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: HH800_RS23300
• Protein ID: WP_169862708.1
• Coordinates: 4842617..4843039 (+)
• Length: 141 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: HH800_RS23295
• Protein ID: WP_169862687.1
• Coordinates: 4842366..4842620 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HH800_RS23280	4838146..4839996	+	1851	WP_206379252.1	strawberry notch C-terminal domain-containing protein	-
HH800_RS23285	4839996..4841030	+	1035	WP_169862683.1	toprim domain-containing protein	-
HH800_RS23290	4841344..4842270	+	927	WP_169862685.1	DUF2493 domain-containing protein	-
HH800_RS23295	4842366..4842620	+	255	WP_169862687.1	plasmid stabilization protein	Antitoxin
HH800_RS23300	4842617..4843039	+	423	WP_169862708.1	type II toxin-antitoxin system VapC family toxin	Toxin
HH800_RS23305	4843321..4843488	+	168	WP_169862710.1	hypothetical protein	-
HH800_RS23310	4843623..4844063	+	441	WP_169862711.1	hypothetical protein	-
HH800_RS23315	4844636..4844962	+	327	WP_041535876.1	DUF736 domain-containing protein	-
HH800_RS23320	4845270..4845536	+	267	WP_128779061.1	helix-turn-helix transcriptional regulator	-
HH800_RS23325	4845633..4845893	+	261	WP_169862713.1	DUF2285 domain-containing protein	-
HH800_RS23330	4846186..4846785	+	600	WP_206379186.1	DUF2285 domain-containing protein	-
HH800_RS23335	4846921..4847202	+	282	WP_169862717.1	helix-turn-helix domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	4825162..4855431	30269

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-123)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 141 a.a.
• Molecular weight: 14910.10 Da
• Isoelectric Point: 4.7392

>T155807 WP_169862708.1 NZ_CP053021:4842617-4843039 [Sphingobium yanoikuyae]
MILLDTNVMSEGMKPAPDDAVRAWLDEQAAETLFLSSVTIAELMFGIGALPDGKRKDRLAEALEGVMELFAHRVLPFDVD
AARRYADLAVKARAAGKGFPTPDGYIAAIAAAKGFAVATRDSSAFDAANVTVIDPWKAGR

Nucleotide

• Length: 423 bp

>T155807 NZ_CP068815:c4978466-4978155 [Escherichia coli]
ATCCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGACCGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTGTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9337.59 Da
• Isoelectric Point: 10.4317

>AT155807 WP_169862687.1 NZ_CP053021:4842366-4842620 [Sphingobium yanoikuyae]
MPAVTIRNLSDATHRALKVRAAQHGRSAEAEMRDILEAAVRPDTRLRLGTALAERSRRLGLTNEDIDALDQSRDKTPAKP
MSFE

Nucleotide

• Length: 255 bp

>AT155807 NZ_CP068815:c4978154-4977864 [Escherichia coli]
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACAGCCTTC
GCGGACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGATC
TTATTTCTGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACCGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAAGCACTTAACCGTTAG