Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 4842366..4843039 Replicon chromosome
Accession NZ_CP053021
Organism Sphingobium yanoikuyae strain YC-XJ2

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag HH800_RS23300 Protein ID WP_169862708.1
Coordinates 4842617..4843039 (+) Length 141 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag HH800_RS23295 Protein ID WP_169862687.1
Coordinates 4842366..4842620 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HH800_RS23280 4838146..4839996 + 1851 WP_206379252.1 strawberry notch C-terminal domain-containing protein -
HH800_RS23285 4839996..4841030 + 1035 WP_169862683.1 toprim domain-containing protein -
HH800_RS23290 4841344..4842270 + 927 WP_169862685.1 DUF2493 domain-containing protein -
HH800_RS23295 4842366..4842620 + 255 WP_169862687.1 plasmid stabilization protein Antitoxin
HH800_RS23300 4842617..4843039 + 423 WP_169862708.1 type II toxin-antitoxin system VapC family toxin Toxin
HH800_RS23305 4843321..4843488 + 168 WP_169862710.1 hypothetical protein -
HH800_RS23310 4843623..4844063 + 441 WP_169862711.1 hypothetical protein -
HH800_RS23315 4844636..4844962 + 327 WP_041535876.1 DUF736 domain-containing protein -
HH800_RS23320 4845270..4845536 + 267 WP_128779061.1 helix-turn-helix transcriptional regulator -
HH800_RS23325 4845633..4845893 + 261 WP_169862713.1 DUF2285 domain-containing protein -
HH800_RS23330 4846186..4846785 + 600 WP_206379186.1 DUF2285 domain-containing protein -
HH800_RS23335 4846921..4847202 + 282 WP_169862717.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4825162..4855431 30269


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 14910.10 Da        Isoelectric Point: 4.7392

>T155807 WP_169862708.1 NZ_CP053021:4842617-4843039 [Sphingobium yanoikuyae]
MILLDTNVMSEGMKPAPDDAVRAWLDEQAAETLFLSSVTIAELMFGIGALPDGKRKDRLAEALEGVMELFAHRVLPFDVD
AARRYADLAVKARAAGKGFPTPDGYIAAIAAAKGFAVATRDSSAFDAANVTVIDPWKAGR

Download         Length: 423 bp

>T155807 NZ_CP068815:c4978466-4978155 [Escherichia coli]
ATCCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGACCGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTGTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9337.59 Da        Isoelectric Point: 10.4317

>AT155807 WP_169862687.1 NZ_CP053021:4842366-4842620 [Sphingobium yanoikuyae]
MPAVTIRNLSDATHRALKVRAAQHGRSAEAEMRDILEAAVRPDTRLRLGTALAERSRRLGLTNEDIDALDQSRDKTPAKP
MSFE

Download         Length: 255 bp

>AT155807 NZ_CP068815:c4978154-4977864 [Escherichia coli]
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACAGCCTTC
GCGGACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGATC
TTATTTCTGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACCGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAAGCACTTAACCGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References