155803

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/ParE-RHH
Location 198..778 Replicon plasmid pKPN361-3
Accession NZ_CP053019
Organism Klebsiella pneumoniae strain KPN361

Toxin (Protein)


Gene name parE Uniprot ID A0A8J3DTL7
Locus tag HJ591_RS28465 Protein ID WP_071177730.1
Coordinates 464..778 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A2X1PRM1
Locus tag HJ591_RS28460 Protein ID WP_000093040.1
Coordinates 198..476 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HJ591_RS28460 198..476 + 279 WP_000093040.1 CopG family ribbon-helix-helix protein Antitoxin
HJ591_RS28465 464..778 + 315 WP_071177730.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HJ591_RS28470 942..1370 + 429 WP_001140599.1 hypothetical protein -
HJ591_RS28475 1396..1575 + 180 WP_000165970.1 Rop family plasmid primer RNA-binding protein -
HJ591_RS28480 1602..2132 - 531 WP_071177729.1 hypothetical protein -
HJ591_RS28485 2139..2870 - 732 WP_071177728.1 replication-relaxation family protein -
HJ591_RS28490 2870..4834 - 1965 WP_071177727.1 TraM recognition domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..10060 10060


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-96)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11805.73 Da        Isoelectric Point: 9.8324

>T155803 WP_071177730.1 NZ_CP053019:464-778 [Klebsiella pneumoniae]
MPQVTISALAQRDLQRLQDFLKTKNRLAARKGGEVIVRAIQQLKTLPDIGRPVPFLPLEYKELVIGFGDSGYVMLYRHDR
EMDQIVIVTVRHQKESGYPGADSL

Download         Length: 315 bp

>T155803 NZ_CP068815:4243904-4244056 [Escherichia coli]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10709.73 Da        Isoelectric Point: 4.7561

>AT155803 WP_000093040.1 NZ_CP053019:198-476 [Klebsiella pneumoniae]
MSSATSIRLDEELKDRLKTLADDRHRSAHALMLEAITEYIDREEKRSQYLRDGQAAWQHYQETGLHLTAEEAEAWISTWG
TENEQDAPPCHR

Download         Length: 279 bp

>AT155803 NZ_CP068815:c4243855-4243798 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2X1PRM1

References