Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4787640..4788156 Replicon chromosome
Accession NZ_CP053016
Organism Klebsiella pneumoniae strain KPN361

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag HJ591_RS23495 Protein ID WP_002886902.1
Coordinates 4787640..4787924 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag HJ591_RS23500 Protein ID WP_002886901.1
Coordinates 4787914..4788156 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HJ591_RS23470 4783124..4783432 - 309 WP_002886907.1 PTS sugar transporter subunit IIB -
HJ591_RS23475 4783517..4783690 + 174 WP_002886906.1 hypothetical protein -
HJ591_RS23480 4783693..4784436 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
HJ591_RS23485 4784793..4786931 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
HJ591_RS23490 4787172..4787636 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
HJ591_RS23495 4787640..4787924 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HJ591_RS23500 4787914..4788156 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HJ591_RS23505 4788234..4790144 - 1911 WP_004152270.1 BglG family transcription antiterminator -
HJ591_RS23510 4790167..4791321 - 1155 WP_002886900.1 lactonase family protein -
HJ591_RS23515 4791387..4792127 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T155794 WP_002886902.1 NZ_CP053016:c4787924-4787640 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T155794 NZ_CP068815:2586237-2586515 [Escherichia coli]
ATGATAATGAATTTCAGACACAAGGGATTGCGTGACTTGTTTCTTCTCGGCAAAACCTCCGGCGTTATACCGACGCAAGT
CAAACGATTACGCCACCGACTCGCTGTGATTGATGCAGCATGCTGTCTTGCTGATATCGATATGCCCGGTTACCGACTAC
ATCCGTTAAGCGGCGATCGCGATGGAATTTGGGCGATATCTGTCTCGGGCAACTGGCGAATCACATTTGAATTCGTCAAT
GGCGATGCATACATACTGGATTACGAGGACTATCACTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT155794 WP_002886901.1 NZ_CP053016:c4788156-4787914 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT155794 NZ_CP068815:2586515-2586799 [Escherichia coli]
ATGAAAATGGCCAATCATCCCCGCCCGGGGGACATTATTCAGGAATCACTGGACGAACTTAATGTCAGCCTGCGCGAGTT
TGCCAGAGCAATGGAAATTGCGCCCTCAACGGCAAGCCGATTGCTGACCGGAAAAGCAGCTTTGACGCCAGAAATGGCAA
TAAAACTTTCCGTGGTGATCGGCAGTTCGCCGCAAATGTGGCTGAATCTGCAAAATGCCTGGAGTCTGGCAGAGGCAGAA
AAAACAGTGGATGTGTCGCGACTGCGCCGTCTGGTTACGCAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References