Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4069391..4070010 Replicon chromosome
Accession NZ_CP053016
Organism Klebsiella pneumoniae strain KPN361

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag HJ591_RS20055 Protein ID WP_002892050.1
Coordinates 4069792..4070010 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag HJ591_RS20050 Protein ID WP_002892066.1
Coordinates 4069391..4069765 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HJ591_RS20040 4064543..4065736 + 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
HJ591_RS20045 4065759..4068905 + 3147 WP_020326861.1 multidrug efflux RND transporter permease subunit -
HJ591_RS20050 4069391..4069765 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
HJ591_RS20055 4069792..4070010 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
HJ591_RS20060 4070169..4070735 + 567 WP_002892030.1 maltose O-acetyltransferase -
HJ591_RS20065 4070707..4070847 - 141 WP_004147370.1 hypothetical protein -
HJ591_RS20070 4070868..4071338 + 471 WP_002892026.1 YlaC family protein -
HJ591_RS20075 4071313..4072764 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
HJ591_RS20080 4072865..4073563 + 699 WP_002892021.1 GNAT family N-acetyltransferase -
HJ591_RS20085 4073560..4073700 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
HJ591_RS20090 4073700..4073963 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T155792 WP_002892050.1 NZ_CP053016:4069792-4070010 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T155792 NZ_CP068815:2248397-2248499 [Escherichia coli]
GCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT155792 WP_002892066.1 NZ_CP053016:4069391-4069765 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT155792 NZ_CP068815:c2248537-2248269 [Escherichia coli]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCTCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References