Detailed information of TA system TA155778

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pasABC/RelE-HTH
• Location: 1690935..1691418
• Replicon: chromosome
• Accession: NZ_CP053015
• Organism: Sphingomonas lacunae strain CSW-10

Toxin (Protein)

• Gene name: pasB
• Uniprot ID: -
• Locus tag: GV829_RS08115
• Protein ID: WP_169945660.1
• Coordinates: 1690935..1691207 (-)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: pasA
• Uniprot ID: -
• Locus tag: GV829_RS08120
• Protein ID: WP_169945662.1
• Coordinates: 1691191..1691418 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GV829_RS08085	1686028..1686777	+	750	WP_169945650.1	sigma-70 family RNA polymerase sigma factor	-
GV829_RS08090	1686805..1687407	-	603	WP_169945652.1	DedA family protein	-
GV829_RS08095	1687449..1688408	-	960	WP_169945654.1	glutathione synthase	-
GV829_RS08100	1688446..1688817	-	372	WP_169945656.1	YraN family protein	-
GV829_RS08105	1688819..1689661	-	843	WP_169945658.1	16S rRNA (cytidine(1402)-2'-O)-methyltransferase	-
GV829_RS08110	1689672..1690850	+	1179	WP_169948115.1	penicillin-binding protein activator	-
GV829_RS08115	1690935..1691207	-	273	WP_169945660.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
GV829_RS08120	1691191..1691418	-	228	WP_169945662.1	TraY domain-containing protein	Antitoxin
GV829_RS08125	1691471..1692124	-	654	WP_169945664.1	fructose-6-phosphate aldolase	-
GV829_RS08130	1692290..1692916	+	627	WP_169945666.1	DUF2490 domain-containing protein	-
GV829_RS08135	1692999..1693700	-	702	WP_169945668.1	DUF4197 domain-containing protein	-
GV829_RS08140	1693806..1695173	+	1368	WP_169948118.1	DNA repair protein RadA	-
GV829_RS08145	1695193..1695738	+	546	WP_169948119.1	CvpA family protein	-
GV829_RS08150	1695743..1696183	+	441	WP_169945670.1	iron-sulfur cluster assembly scaffold protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-88)

Antitoxin

• Relaxosome protein TraY (3-43)

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 10572.21 Da
• Isoelectric Point: 10.8525

>T155778 WP_169945660.1 NZ_CP053015:c1691207-1690935 [Sphingomonas lacunae]
MAWRIEFADSAAKQLRKFDPQTATRILTFVRDRLARLDDPRSIGEALRGKELGSFWKYRVGDYRIIADLDDGVMLITVVR
LGNRREVYRR

Nucleotide

• Length: 273 bp

>T155778 NZ_CP068814:4602913-4603170 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGCCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8161.24 Da
• Isoelectric Point: 4.3696

>AT155778 WP_169945662.1 NZ_CP053015:c1691418-1691191 [Sphingomonas lacunae]
MPISLRLPADVENRLAALSTLTGRSKTFYATEAIIEHIDDLEDAHLSAEVLARVRAGTEARIPLNDLLADYGLAD

Nucleotide

• Length: 228 bp

>AT155778 NZ_CP068814:4603182-4603733 [Escherichia coli]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCGACCTTCAAAGGAGAAATGGATTCACCGCTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCGCAGGCCCTGATGAAACCGGAGCACTGGCGTGAATAA