Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 3714687..3716275 Replicon chromosome
Accession NZ_CP053014
Organism Dickeya zeae strain MS_2018

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag HJ586_RS16605 Protein ID WP_038914945.1
Coordinates 3714687..3716006 (-) Length 440 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag HJ586_RS16610 Protein ID WP_038915205.1
Coordinates 3716006..3716275 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HJ586_RS16595 (HJ586_16610) 3709847..3711124 + 1278 WP_236305233.1 FRG domain-containing protein -
HJ586_RS16600 (HJ586_16615) 3711121..3714270 + 3150 WP_236305240.1 type I restriction endonuclease subunit R -
HJ586_RS16605 (HJ586_16620) 3714687..3716006 - 1320 WP_038914945.1 type II toxin-antitoxin system HipA family toxin Toxin
HJ586_RS16610 (HJ586_16625) 3716006..3716275 - 270 WP_038915205.1 helix-turn-helix domain-containing protein Antitoxin
HJ586_RS16615 (HJ586_16630) 3716452..3717429 - 978 WP_236305242.1 helix-turn-helix domain-containing protein -
HJ586_RS16620 (HJ586_16635) 3717473..3718246 - 774 WP_226067660.1 MBL fold metallo-hydrolase -
HJ586_RS16625 (HJ586_16640) 3718565..3719653 + 1089 WP_236305244.1 4-hydroxyphenylpyruvate dioxygenase -
HJ586_RS16630 (HJ586_16645) 3719790..3720176 - 387 WP_236306908.1 helix-turn-helix domain-containing protein -
HJ586_RS16635 (HJ586_16650) 3720319..3720930 + 612 WP_236305246.1 NAD(P)-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 440 a.a.        Molecular weight: 49347.57 Da        Isoelectric Point: 6.9261

>T155777 WP_038914945.1 NZ_CP053014:c3716006-3714687 [Dickeya zeae]
MAALDVYMNGYRVGILTKTGSGAHHFSYDVNWLGLSGSRPISLSMPLRHQPYQGDEVYNFFDNLLPDNPDIRRRIVARHH
ADSTQPFDLLAKVGRDSVGALQLIPASTPTNNIKQIEYKTLSEQQLENILSGYLVDAPLGMIDTEDDFRISIAGAQEKTA
LLYRDNHWCLPFNTTPTTHIIKLPIGKIESHSYSIDMSDSVENEYLCLLIAREFGLPVPHCFMLNAGKIKALAVERFDRK
YASDGSWVMRLPQEDFCQVLNVPSALKYENHGGPGISAIMSYLLGAVDPQRDRYSFMKVQVLFWLLAATDGHAKNFSLFI
EPEGRYRLTPFYDILSMYPAMGGRGIDRREAKLAMGLASSKGKKYAIEQIFPRHFFQTAQAVGFARESMESILTEFAQSM
DTIVMKIRNQLPASFPASIRDAILEGMQARAGRLMTGWE

Download         Length: 1320 bp

>T155777 NZ_CP068814:c4557622-4557413 [Escherichia coli]
ATGGTTGATTATCCAAAACGTGATGCTATTTCCAACATCAACGCTATAATTGTAGATACATTTTTGTATATACAATTAGG
GATGGCAACTATGCCAATGGAGTTTGAATGGAATGCAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTG
AAGATGCGGTGTTAGTGCTTGATGATCCACAACGAACGGAGCCGCTATGA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10048.39 Da        Isoelectric Point: 8.5848

>AT155777 WP_038915205.1 NZ_CP053014:c3716275-3716006 [Dickeya zeae]
MKVTNSKQLSSYLKDVRIMQKLSQGKVASKVGIRQDTVSSFEQHPDSTKLETFFKILSALNLELTVTPRNMDAANNEASV
AESSWKEEW

Download         Length: 270 bp

>AT155777 NZ_CP068814:c4557416-4557114 [Escherichia coli]
ATGAGCATGGTTAAACATAAACGAGGGACCTCCTCTACACTCGATGTGCAGCATGAGGCCGAACTGAAGGTGCTGGCGAA
CAAATTCGACGAGGATATTGATTACAGCGACATCCCATCTTCCAGCGATGAGCAATGGTCTAACGCAGAACGCGGTAAGT
TTTATCGGCCATTGAAAACTCAGGCTTCGGTGCGTATTGATGCTGATGTGATGGAATGGTTGAAGCGACCAGGTAAAGGC
TATCAAACTCGCCTGAACGCAATTTTACGTGAAGCGATGCTGCGCGATCAGAACAAAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References