Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2978244..2978922 Replicon chromosome
Accession NZ_CP053014
Organism Dickeya zeae strain MS_2018

Toxin (Protein)


Gene name cptA Uniprot ID D2BSA8
Locus tag HJ586_RS13255 Protein ID WP_012883372.1
Coordinates 2978244..2978675 (-) Length 144 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A2K9QKF2
Locus tag HJ586_RS13260 Protein ID WP_016943577.1
Coordinates 2978656..2978922 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HJ586_RS13235 (HJ586_13245) 2974169..2974885 - 717 WP_019846265.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HJ586_RS13240 (HJ586_13250) 2974972..2975871 - 900 WP_016943580.1 site-specific tyrosine recombinase XerD -
HJ586_RS13245 (HJ586_13255) 2976135..2977460 + 1326 WP_012883374.1 MFS transporter -
HJ586_RS13250 (HJ586_13260) 2977637..2978155 + 519 WP_236304980.1 flavodoxin FldB -
HJ586_RS13255 (HJ586_13265) 2978244..2978675 - 432 WP_012883372.1 protein YgfX Toxin
HJ586_RS13260 (HJ586_13270) 2978656..2978922 - 267 WP_016943577.1 FAD assembly factor SdhE Antitoxin
HJ586_RS13265 (HJ586_13275) 2979232..2980212 + 981 WP_236304981.1 tRNA-modifying protein YgfZ -
HJ586_RS13270 (HJ586_13280) 2980289..2980939 - 651 WP_038913159.1 hemolysin III family protein -
HJ586_RS13275 (HJ586_13285) 2981152..2981760 + 609 WP_019846260.1 HD domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 144 a.a.        Molecular weight: 16887.54 Da        Isoelectric Point: 11.5023

>T155776 WP_012883372.1 NZ_CP053014:c2978675-2978244 [Dickeya zeae]
VAQWQCDLRVSWRMQLFSLLTHGFLMLMILLAPWPDGYAPLWLGLVTLVVFDFVRSQRSIKSRQGEISLRGDNQLHWQQR
DWQIVRRPWFMRNGVLLSLRAVDGKGQQRLWLASDSMGSEEWRLLRQQLQQPALHGTESSRHH

Download         Length: 432 bp

>T155776 NZ_CP068814:c4216198-4215800 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCGTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGTGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAGCCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGAAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10404.88 Da        Isoelectric Point: 5.5981

>AT155776 WP_016943577.1 NZ_CP053014:c2978922-2978656 [Dickeya zeae]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDTLSDDDKQQFIRLLQCDDPDLFNWLMNHGEPGDPGLKRMVSLIQTRN
KDRGPVAM

Download         Length: 267 bp

>AT155776 NZ_CP068814:c4216494-4216201 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAATCCAGCAAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CAGAACAAGAGGAGAAAAAACTGGTGAAGGCGCGCTTCCGTCCGAGTGCCGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K9QB06

Antitoxin

Source ID Structure
AlphaFold DB A0A2K9QKF2

References