155774

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 2091191..2091744 Replicon chromosome
Accession NZ_CP053014
Organism Dickeya zeae strain MS_2018

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag HJ586_RS09420 Protein ID WP_110371742.1
Coordinates 2091191..2091505 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID -
Locus tag HJ586_RS09425 Protein ID WP_038915937.1
Coordinates 2091508..2091744 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HJ586_RS09395 (HJ586_09415) 2086317..2087339 + 1023 WP_026358149.1 IS110 family transposase -
HJ586_RS09400 (HJ586_09420) 2087562..2087678 - 117 Protein_1839 transposase -
HJ586_RS09405 (HJ586_09425) 2087996..2090185 - 2190 WP_236306652.1 hypothetical protein -
HJ586_RS09410 2090901..2091029 + 129 Protein_1841 integrase -
HJ586_RS09415 (HJ586_09435) 2091069..2091194 + 126 Protein_1842 molybdopterin-guanine dinucleotide biosynthesis protein MobC -
HJ586_RS09420 (HJ586_09440) 2091191..2091505 - 315 WP_110371742.1 CcdB family protein Toxin
HJ586_RS09425 (HJ586_09445) 2091508..2091744 - 237 WP_038915937.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
HJ586_RS09430 (HJ586_09450) 2091887..2092798 - 912 WP_038915936.1 LysR substrate-binding domain-containing protein -
HJ586_RS09435 (HJ586_09455) 2092921..2093697 + 777 WP_019844785.1 2OG-Fe dioxygenase family protein -
HJ586_RS09440 (HJ586_09460) 2093754..2094371 + 618 WP_019844784.1 LysE family translocator -
HJ586_RS09445 (HJ586_09465) 2094386..2095030 + 645 WP_019844783.1 bifunctional phosphoserine phosphatase/homoserine phosphotransferase ThrH -
HJ586_RS09450 (HJ586_09470) 2095201..2095377 - 177 Protein_1849 zincin-like metallopeptidase domain-containing protein -
HJ586_RS09455 (HJ586_09475) 2095464..2096465 - 1002 WP_236306653.1 NADP-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-103)

Antitoxin

Post-segregation antitoxin CcdA

(9-78)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11517.46 Da        Isoelectric Point: 7.9859

>T155774 WP_110371742.1 NZ_CP053014:c2091505-2091191 [Dickeya zeae]
MQFTVYGNTGKSTIYPLLLDVTSDIIGQLNRRIVIPLLPVEKYPAGRRPDRLVPVVRLTDGKEYAVMTHELASIPVQALG
AVFCDASQYRTQIKAAIDFLIDGI

Download         Length: 315 bp

>T155774 NZ_CP068814:3996683-3996901 [Escherichia coli]
ATGTCCGAAAAACCTTTAACAAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 9064.12 Da        Isoelectric Point: 6.7184

>AT155774 WP_038915937.1 NZ_CP053014:c2091744-2091508 [Dickeya zeae]
MTAKQRNTQSVTMTVERALLLRAREAGINLSATLTAALDAELRRHEAKKWQEENREAIDALNRFHDEHSCFSDEYRTF

Download         Length: 237 bp

>AT155774 NZ_CP068814:3996283-3996657 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGCAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References