Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 1664047..1664600 Replicon chromosome
Accession NZ_CP053013
Organism Dickeya zeae strain MS_2014

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag HJ580_RS07405 Protein ID WP_102801434.1
Coordinates 1664286..1664600 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID A0A2K9QDB2
Locus tag HJ580_RS07400 Protein ID WP_049855373.1
Coordinates 1664047..1664283 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HJ580_RS07380 (HJ580_07395) 1659738..1660523 + 786 WP_019844778.1 SDR family oxidoreductase -
HJ580_RS07385 (HJ580_07400) 1660632..1661444 + 813 WP_102801433.1 oxidoreductase -
HJ580_RS07390 (HJ580_07405) 1661621..1662613 + 993 WP_199770320.1 MDR family oxidoreductase -
HJ580_RS07395 (HJ580_07410) 1662802..1663803 + 1002 WP_038913604.1 NADP-dependent oxidoreductase -
HJ580_RS07400 (HJ580_07415) 1664047..1664283 + 237 WP_049855373.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
HJ580_RS07405 (HJ580_07420) 1664286..1664600 + 315 WP_102801434.1 CcdB family protein Toxin
HJ580_RS07410 (HJ580_07425) 1664994..1665797 - 804 WP_102801435.1 carboxymuconolactone decarboxylase family protein -
HJ580_RS07415 (HJ580_07430) 1665813..1666508 - 696 WP_199770335.1 antibiotic biosynthesis monooxygenase -
HJ580_RS07420 (HJ580_07435) 1666568..1667587 - 1020 WP_102801436.1 aldo/keto reductase -
HJ580_RS07425 (HJ580_07440) 1667606..1668163 - 558 WP_102801437.1 NAD(P)H-dependent oxidoreductase -
HJ580_RS07430 (HJ580_07445) 1668316..1669350 - 1035 WP_102801438.1 amidohydrolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-103)

Antitoxin

Post-segregation antitoxin CcdA

(9-78)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11462.36 Da        Isoelectric Point: 7.9859

>T155751 WP_102801434.1 NZ_CP053013:1664286-1664600 [Dickeya zeae]
MQFTVYGNTGKSGVYPLLLDVTSDIIGQLNRRIVIPLLPVEKYPAGRRPDRLVPAIRLTDGKEYAVMTHELASIPVQALG
AVFCDASQYRNQVKAAMDFLIDGI

Download         Length: 315 bp

>T155751 NZ_CP068813:c5028159-5027848 [Escherichia coli]
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGACCGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTCACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTGTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 9024.99 Da        Isoelectric Point: 5.1184

>AT155751 WP_049855373.1 NZ_CP053013:1664047-1664283 [Dickeya zeae]
MTAKQRNTQSVTMTVERALLVRAREAGINLSATLSTALDAELRRYEANKWQEENREAIDALNRFHDENGCFSDEYRTF

Download         Length: 237 bp

>AT155751 NZ_CP068813:c5027847-5027557 [Escherichia coli]
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACACCCTTC
ACGGACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGAAC
TTATTTCCGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACTGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAGGCACTTAACCGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2K9QDB2

References