Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1218218..1218843 Replicon chromosome
Accession NZ_CP053013
Organism Dickeya zeae strain MS_2014

Toxin (Protein)


Gene name Hha Uniprot ID E0SD87
Locus tag HJ580_RS05540 Protein ID WP_009114000.1
Coordinates 1218218..1218421 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID D2BUK3
Locus tag HJ580_RS05545 Protein ID WP_012883774.1
Coordinates 1218475..1218843 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HJ580_RS05510 (HJ580_05525) 1213845..1214183 + 339 WP_002208627.1 P-II family nitrogen regulator -
HJ580_RS05515 (HJ580_05530) 1214227..1215519 + 1293 WP_102801261.1 ammonium transporter AmtB -
HJ580_RS05520 (HJ580_05535) 1215640..1216503 - 864 WP_023639171.1 acyl-CoA thioesterase II -
HJ580_RS05525 (HJ580_05540) 1216721..1217302 + 582 WP_102801262.1 YbaY family lipoprotein -
HJ580_RS05530 (HJ580_05545) 1217343..1217669 - 327 WP_012883773.1 MGMT family protein -
HJ580_RS05540 (HJ580_05555) 1218218..1218421 - 204 WP_009114000.1 HHA domain-containing protein Toxin
HJ580_RS05545 (HJ580_05560) 1218475..1218843 - 369 WP_012883774.1 Hha toxicity modulator TomB Antitoxin
HJ580_RS05550 (HJ580_05565) 1219353..1219496 - 144 WP_012770724.1 type B 50S ribosomal protein L36 -
HJ580_RS05555 (HJ580_05570) 1219512..1219763 - 252 WP_019844635.1 type B 50S ribosomal protein L31 -
HJ580_RS05560 (HJ580_05575) 1219939..1223085 - 3147 WP_019844634.1 efflux RND transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8133.51 Da        Isoelectric Point: 8.8500

>T155750 WP_009114000.1 NZ_CP053013:c1218421-1218218 [Dickeya zeae]
MKKIDYLMRLRKCTTIDTLERVIEKNKYELSNDELEMFYSAADHRLAELTMNKLYDKVPTAVWKYVR

Download         Length: 204 bp

>T155750 NZ_CP068813:c4732037-4731864 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14186.04 Da        Isoelectric Point: 5.1811

>AT155750 WP_012883774.1 NZ_CP053013:c1218843-1218475 [Dickeya zeae]
MDEYTPQHYDIAQLRFLCENLHDESIATLGDSSRGWVNDPTSAVNLQLNELIEHIAAFVVTYKIKYPHEAALCERVEKYL
DDTYILFSNYGINDSELQKWKKSKSQLFRMFSEKSVCTVVKT

Download         Length: 369 bp

>AT155750 NZ_CP068813:c4732361-4732065 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAATT
CCTTCGCAATAACGACATCATTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1X3RNQ0

Antitoxin

Source ID Structure
AlphaFold DB A0A2K9QCC2

References