Detailed information of TA system TA155747

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 580064..580842
• Replicon: chromosome
• Accession: NZ_CP053013
• Organism: Dickeya zeae strain MS_2014

Toxin (Protein)

• Gene name: TacT2
• Uniprot ID: -
• Locus tag: HJ580_RS02620
• Protein ID: WP_102800985.1
• Coordinates: 580354..580842 (+)
• Length: 163 a.a.

Antitoxin (Protein)

• Gene name: TacA2
• Uniprot ID: A0A2K9QAQ0
• Locus tag: HJ580_RS02615
• Protein ID: WP_038903249.1
• Coordinates: 580064..580357 (+)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HJ580_RS02590 (HJ580_02590)	575224..576435	+	1212	WP_102800980.1	glycosyltransferase family 4 protein	-
HJ580_RS02595 (HJ580_02595)	576437..577540	+	1104	WP_102800981.1	glycosyltransferase family 4 protein	-
HJ580_RS02600 (HJ580_02600)	577587..577994	+	408	WP_102800982.1	hypothetical protein	-
HJ580_RS02605 (HJ580_02605)	578032..579426	+	1395	WP_102800983.1	DUF4832 domain-containing protein	-
HJ580_RS02610 (HJ580_02610)	579456..579956	+	501	WP_102800984.1	serine acetyltransferase	-
HJ580_RS02615 (HJ580_02615)	580064..580357	+	294	WP_038903249.1	DUF1778 domain-containing protein	Antitoxin
HJ580_RS02620 (HJ580_02620)	580354..580842	+	489	WP_102800985.1	GNAT family N-acetyltransferase	Toxin
HJ580_RS02625 (HJ580_02625)	581000..583201	+	2202	WP_102800986.1	AAA family ATPase	-
HJ580_RS02630 (HJ580_02630)	583572..583877	-	306	WP_102800987.1	type II toxin-antitoxin system toxin CcdB	-
HJ580_RS02635 (HJ580_02635)	583880..584098	-	219	WP_102800988.1	type II toxin-antitoxin system antitoxin CcdA	-
HJ580_RS02640	584157..584410	-	254	Protein_513	molybdopterin-guanine dinucleotide biosynthesis protein MobC	-
HJ580_RS02650 (HJ580_02645)	584773..585348	-	576	WP_102800989.1	transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (44-143)

Antitoxin

• Vibrio phage ICP1, Orf50 (4-95)

Sequences

Toxin

Protein

• Length: 163 a.a.
• Molecular weight: 17467.28 Da
• Isoelectric Point: 7.2147

>T155747 WP_102800985.1 NZ_CP053013:580354-580842 [Dickeya zeae]
MISAPEPLRAEHVLSSFCCGVESMDNWLKQRAMKNQVTGASRTFVSCDDSKVLAYYSLASSAVATNFAPGRFRRNMPDPI
PVVVLGRLAVDTSLHGQGVGRALVRDAGLRVIQVADTIGIRGMLVHALSDEARAFYLQVGFEPSLIDPMMLMVTLGDLVG
SV

Nucleotide

• Length: 489 bp

>T155747 NZ_CP068813:c4143392-4142994 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCGTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGTGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAGCCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGAAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 10902.47 Da
• Isoelectric Point: 10.1968

>AT155747 WP_038903249.1 NZ_CP053013:580064-580357 [Dickeya zeae]
MPATNSVSVKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIDQRIIMADPDAYQEFLTRLDQAPSPN
AALRKTMQTPAPWEQKK

Nucleotide

• Length: 294 bp

>AT155747 NZ_CP068813:c4143688-4143395 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAATCCAGCAAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CAGAACAAGAGGAGAAAAAACTGGTGAAGGCGCGCTTCCGTCCGAGTGCCGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Structures

Antitoxin

• AlphaFold DB: A0A2K9QAQ0