Detailed information of TA system TA155737

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): DhiAT/dnstrm_HI1420(antitoxin)
• Location: 1747916..1748666
• Replicon: chromosome
• Accession: NZ_CP053012
• Organism: Dickeya zeae MS1

Toxin (Protein)

• Gene name: dhiT
• Uniprot ID: -
• Locus tag: J417_RS07790
• Protein ID: WP_019844839.1
• Coordinates: 1747916..1748173 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: dhiA
• Uniprot ID: -
• Locus tag: J417_RS07795
• Protein ID: WP_019844840.1
• Coordinates: 1748181..1748666 (+)
• Length: 162 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J417_RS07770 (J417_07785)	1743083..1744396	-	1314	WP_019844835.1	aminotransferase class III-fold pyridoxal phosphate-dependent enzyme	-
J417_RS07775 (J417_07790)	1744435..1745472	-	1038	WP_019844836.1	phosphotransferase	-
J417_RS07780 (J417_07795)	1745465..1746199	-	735	WP_019844837.1	SDR family oxidoreductase	-
J417_RS07785 (J417_07800)	1746326..1747354	-	1029	WP_019844838.1	ABC transporter substrate-binding protein	-
J417_RS07790 (J417_07805)	1747916..1748173	+	258	WP_019844839.1	DUF4160 domain-containing protein	Toxin
J417_RS07795 (J417_07810)	1748181..1748666	+	486	WP_019844840.1	addiction module antitoxin	Antitoxin
J417_RS07800 (J417_07815)	1748755..1749249	-	495	WP_019844841.1	hydrogenase maturation peptidase HycI	-
J417_RS07805 (J417_07820)	1749242..1749640	-	399	WP_019844842.1	formate hydrogenlyase maturation HycH family protein	-
J417_RS07810 (J417_07825)	1749640..1750428	-	789	WP_012885279.1	NADH-quinone oxidoreductase subunit B family protein	-
J417_RS07815 (J417_07830)	1750425..1750994	-	570	WP_019844843.1	hydrogenase 4 subunit H	-
J417_RS07820 (J417_07835)	1751005..1752732	-	1728	WP_019844844.1	hydrogenase large subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF4160 (9-73)

Antitoxin

• Uncharacterized protein HI1420 (80-156)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9851.50 Da
• Isoelectric Point: 7.5565

>T155737 WP_019844839.1 NZ_CP053012:1747916-1748173 [Dickeya zeae MS1]
MPEIDRLAGLIFHLYFYDDERHHLPHVHVCYGNHELIISIRTGIEIEGYLPNTKRKLAIAHIMAHREQLLSMWAQAVIGK
NPGKL

Nucleotide

• Length: 258 bp

>T155737 NZ_CP068813:1304096-1304407 [Escherichia coli]
ATGCACATCATTTCGAAAGCGCCATTTGAAGAGTGTGCGCGCAAATATCCTAACGACGCTCTGGCTCTACACTCATTGTA
TCGGGTTATTAAGGAAACGGATTTTTCTACACCAGAAGAAATGCGAACGGCGTTTCCTAACCTCGACAATTTTAAATATC
GCAACAAATGGTACGTTCTGGATGTCGGCGGGAACAATCTTAGGGTTATTGCCTACATAAACTTTGTTAATAAGCGGTTC
TTTGTGAAGCACATAACGAATCACGCAGAGTATGACAAACTGACACGTTACTACAGAGAGAACAAAGAATGA

Antitoxin

Protein

• Length: 162 a.a.
• Molecular weight: 17950.37 Da
• Isoelectric Point: 6.9893

>AT155737 WP_019844840.1 NZ_CP053012:1748181-1748666 [Dickeya zeae MS1]
MHKIVDVDVVGDFSLRLTYDDGLIYDVNLYRYASYPVFSHTSQFIRFGLLPDGSLEWPDITISSSALREKGTYVGHTLAV
RERNFADIISRAFYDAVIENRPEILQAALKIAVDKHGNSTVAKEAGAKSRTSLYKSLNKNTNVSLATVVSLAHTVLQLEE
K

Nucleotide

• Length: 486 bp

>AT155737 NZ_CP068813:1304404-1304823 [Escherichia coli]
ATGACTGCTAATGCTGCACGCGCTGTTAAAGCAACAAGAGAACTGGTCAATGCAGTCCCCTTTCTGGGAGGCAGTGACTC
AGAAGATGATTATCGTGAAGCACTGGAACTGGTCGAATATTTGATTGAAGAAGATGACACCAATCCACTTATCGACTTTC
TGGCGAGCCGCATTGCAGAATATGAAAACAACAACGAAAAGTTTGCAGAGTTCGACAAAGCCGTTGCAGCAATGCCGGTT
GGCGTGGCCTTACTTCGTACGCTGATTGATCAACATAATTTGACCTATGCGGATTTGAAGAACGAAATCGGCTCTAAATC
TCTGGTCAGTCAGATTTTGTCTGGGCAACGATCCCTGACGATATCCCATATTAAGGCACTTTCAGCCCGATTTGGCGTTA
AGCCGGAATGGTTTCTTTGA