Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 1675819..1676372 Replicon chromosome
Accession NZ_CP053012
Organism Dickeya zeae MS1

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag J417_RS07450 Protein ID WP_019844788.1
Coordinates 1676058..1676372 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID -
Locus tag J417_RS07445 Protein ID WP_019844787.1
Coordinates 1675819..1676055 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J417_RS07415 (J417_07435) 1671098..1672100 + 1003 Protein_1444 NADP-dependent oxidoreductase -
J417_RS07420 (J417_07440) 1672187..1672362 + 176 Protein_1445 zincin-like metallopeptidase domain-containing protein -
J417_RS07425 (J417_07445) 1672533..1673177 - 645 WP_019844783.1 bifunctional phosphoserine phosphatase/homoserine phosphotransferase ThrH -
J417_RS07430 (J417_07450) 1673192..1673809 - 618 WP_019844784.1 LysE family translocator -
J417_RS07435 (J417_07455) 1673866..1674642 - 777 WP_019844785.1 2OG-Fe dioxygenase family protein -
J417_RS07440 (J417_07460) 1674765..1675676 + 912 WP_019844786.1 LysR substrate-binding domain-containing protein -
J417_RS07445 (J417_07465) 1675819..1676055 + 237 WP_019844787.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
J417_RS07450 (J417_07470) 1676058..1676372 + 315 WP_019844788.1 CcdB family protein Toxin
J417_RS07455 (J417_07475) 1676369..1676494 - 126 Protein_1452 molybdopterin-guanine dinucleotide biosynthesis protein MobC -
J417_RS07460 (J417_07485) 1677009..1679027 - 2019 WP_019844789.1 ATP-binding protein -
J417_RS07465 (J417_07490) 1679024..1680403 - 1380 WP_019844790.1 DUF4263 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-103)

Antitoxin

Post-segregation antitoxin CcdA

(9-78)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11531.49 Da        Isoelectric Point: 7.9859

>T155735 WP_019844788.1 NZ_CP053012:1676058-1676372 [Dickeya zeae MS1]
MQFTVYGNTGKSTIYPLLLDVTSDIIGQLNRRIVIPLLPVEKYPAARRPDRLVPVVRLTDGKEYAVMTHELASIPVQALG
AVFCDASQYRTQIKAAIDFLIDGI

Download         Length: 315 bp

>T155735 NZ_CP068813:1083608-1084015 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCCTGTTGATGGACGGGCGTTTGCGCTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 9050.09 Da        Isoelectric Point: 6.7184

>AT155735 WP_019844787.1 NZ_CP053012:1675819-1676055 [Dickeya zeae MS1]
MTAKQRNTQSVTMTVERALLVRAREAGINLSATLTAALDAELRRHEAKKWQEENREAIDALNRFHDEHSCFSDEYRTF

Download         Length: 237 bp

>AT155735 NZ_CP068813:1083361-1083627 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGATGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References