Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1219909..1220534 Replicon chromosome
Accession NZ_CP053012
Organism Dickeya zeae MS1

Toxin (Protein)


Gene name Hha Uniprot ID E0SD87
Locus tag J417_RS05540 Protein ID WP_009114000.1
Coordinates 1219909..1220112 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID D2BUK3
Locus tag J417_RS05545 Protein ID WP_012883774.1
Coordinates 1220166..1220534 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J417_RS05510 (J417_05525) 1215512..1215850 + 339 WP_002208627.1 P-II family nitrogen regulator -
J417_RS05515 (J417_05530) 1215894..1217186 + 1293 WP_019844639.1 ammonium transporter AmtB -
J417_RS05520 (J417_05535) 1217310..1218173 - 864 WP_019844638.1 acyl-CoA thioesterase II -
J417_RS05525 (J417_05540) 1218391..1218972 + 582 WP_019844637.1 YbaY family lipoprotein -
J417_RS05530 (J417_05545) 1219013..1219339 - 327 WP_019844636.1 MGMT family protein -
J417_RS05540 (J417_05555) 1219909..1220112 - 204 WP_009114000.1 HHA domain-containing protein Toxin
J417_RS05545 (J417_05560) 1220166..1220534 - 369 WP_012883774.1 Hha toxicity modulator TomB Antitoxin
J417_RS05550 (J417_05565) 1221044..1221187 - 144 WP_012770724.1 type B 50S ribosomal protein L36 -
J417_RS05555 (J417_05570) 1221203..1221454 - 252 WP_019844635.1 type B 50S ribosomal protein L31 -
J417_RS05560 (J417_05575) 1221633..1224779 - 3147 WP_019844634.1 efflux RND transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8133.51 Da        Isoelectric Point: 8.8500

>T155734 WP_009114000.1 NZ_CP053012:c1220112-1219909 [Dickeya zeae MS1]
MKKIDYLMRLRKCTTIDTLERVIEKNKYELSNDELEMFYSAADHRLAELTMNKLYDKVPTAVWKYVR

Download         Length: 204 bp

>T155734 NZ_CP068813:c957971-957597 [Escherichia coli]
ATGAAAACATTATCCGACACACATGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTACGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATCAACAGCATTGATATTCTCCGGGCACGCCGGGCAACAGGTCTGATGACCCGCAG
CAACTACAGAACGGTAAATAACATTACCCAGGGCAAGCATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14186.04 Da        Isoelectric Point: 5.1811

>AT155734 WP_012883774.1 NZ_CP053012:c1220534-1220166 [Dickeya zeae MS1]
MDEYTPQHYDIAQLRFLCENLHDESIATLGDSSRGWVNDPTSAVNLQLNELIEHIAAFVVTYKIKYPHEAALCERVEKYL
DDTYILFSNYGINDSELQKWKKSKSQLFRMFSEKSVCTVVKT

Download         Length: 369 bp

>AT155734 NZ_CP068813:c958392-958018 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACGCTTCCCGACGACAATAACGACCGCACCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTTGGGGCACGTCTGGTACAGGAAGGCAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGGCGGT
TCAGCGACGCAGATGCATACCATCCGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGTTACGTTTATCTGGCGGTTTATCCGACACCGGCACCCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1X3RNQ0

Antitoxin

Source ID Structure
AlphaFold DB A0A2K9QCC2

References