Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1015514..1016298 Replicon chromosome
Accession NZ_CP053012
Organism Dickeya zeae MS1

Toxin (Protein)


Gene name TacT2 Uniprot ID -
Locus tag J417_RS04610 Protein ID WP_019844369.1
Coordinates 1015804..1016298 (+) Length 165 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID -
Locus tag J417_RS04605 Protein ID WP_019844370.1
Coordinates 1015514..1015807 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J417_RS04585 (J417_04595) 1013552..1014139 - 588 WP_019844374.1 hypothetical protein -
J417_RS04590 (J417_04600) 1014196..1014456 - 261 WP_019844373.1 helix-turn-helix transcriptional regulator -
J417_RS04595 (J417_04605) 1014561..1014821 - 261 WP_019844372.1 helix-turn-helix transcriptional regulator -
J417_RS04600 (J417_04610) 1014942..1015238 + 297 WP_172640055.1 helix-turn-helix transcriptional regulator -
J417_RS04605 (J417_04615) 1015514..1015807 + 294 WP_019844370.1 DUF1778 domain-containing protein Antitoxin
J417_RS04610 (J417_04620) 1015804..1016298 + 495 WP_019844369.1 GNAT family N-acetyltransferase Toxin
J417_RS04615 (J417_04625) 1016912..1017949 + 1038 WP_019844368.1 nucleotidyltransferase -
J417_RS04620 (J417_04630) 1017946..1019682 + 1737 WP_019844367.1 ThiF family adenylyltransferase -
J417_RS04625 (J417_04635) 1019699..1020145 + 447 WP_236377695.1 Mov34/MPN/PAD-1 family protein -
J417_RS04630 (J417_04640) 1020155..1021222 + 1068 WP_019844365.1 SAVED domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 989317..1023120 33803


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(76-143)

Antitoxin

Vibrio phage ICP1, Orf50

(5-95)


Sequences

Toxin        


Download         Length: 165 a.a.        Molecular weight: 17600.39 Da        Isoelectric Point: 7.2921

>T155732 WP_019844369.1 NZ_CP053012:1015804-1016298 [Dickeya zeae MS1]
MISAPEPLHTEHALSSFCCGVESMDNWLKQRAMKNQVTGASRTFVSCDGSKVLAYYSLASSAVATNAAPGRFRRNMPDPI
PVVVLGRLAVDTSLHGQGIGRALVRDAGLRVIQVADTIGIRGMLVHALSDEARDFYLRVGFEPSPIDPMMLMVTLGDLVG
SLSI

Download         Length: 495 bp

>T155732 NZ_CP068813:c676262-675798 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTACAGCGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAGACAGAAGAAGCCCATTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10884.50 Da        Isoelectric Point: 10.1968

>AT155732 WP_019844370.1 NZ_CP053012:1015514-1015807 [Dickeya zeae MS1]
MPVTNSVSVKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIDQRIIMADPDAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQKK

Download         Length: 294 bp

>AT155732 NZ_CP068813:c676597-676262 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCGACACTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References