Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 702403..703081 Replicon chromosome
Accession NZ_CP053012
Organism Dickeya zeae MS1

Toxin (Protein)


Gene name cptA Uniprot ID D2BSA8
Locus tag J417_RS03220 Protein ID WP_012883372.1
Coordinates 702650..703081 (+) Length 144 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A2K9QKF2
Locus tag J417_RS03215 Protein ID WP_016943577.1
Coordinates 702403..702669 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J417_RS03200 (J417_03195) 699571..700179 - 609 WP_019846260.1 HD domain-containing protein -
J417_RS03205 (J417_03200) 700392..701042 + 651 WP_019846261.1 hemolysin III family protein -
J417_RS03210 (J417_03205) 701113..702093 - 981 WP_019846262.1 tRNA-modifying protein YgfZ -
J417_RS03215 (J417_03210) 702403..702669 + 267 WP_016943577.1 FAD assembly factor SdhE Antitoxin
J417_RS03220 (J417_03215) 702650..703081 + 432 WP_012883372.1 protein YgfX Toxin
J417_RS03225 (J417_03220) 703170..703688 - 519 WP_016943578.1 flavodoxin FldB -
J417_RS03230 (J417_03225) 703842..705167 - 1326 WP_012883374.1 MFS transporter -
J417_RS03235 (J417_03230) 705431..706330 + 900 WP_016943580.1 site-specific tyrosine recombinase XerD -
J417_RS03240 (J417_03235) 706417..707133 + 717 WP_019846265.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 144 a.a.        Molecular weight: 16887.54 Da        Isoelectric Point: 11.5023

>T155731 WP_012883372.1 NZ_CP053012:702650-703081 [Dickeya zeae MS1]
VAQWQCDLRVSWRMQLFSLLTHGFLMLMILLAPWPDGYAPLWLGLVTLVVFDFVRSQRSIKSRQGEISLRGDNQLHWQQR
DWQIVRRPWFMRNGVLLSLRAVDGKGQQRLWLASDSMGSEEWRLLRQQLQQPALHGTESSRHH

Download         Length: 432 bp

>T155731 NZ_CP068813:263303-263410 [Escherichia coli]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CATGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10404.88 Da        Isoelectric Point: 5.5981

>AT155731 WP_016943577.1 NZ_CP053012:702403-702669 [Dickeya zeae MS1]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDTLSDDDKQQFIRLLQCDDPDLFNWLMNHGEPGDPGLKRMVSLIQTRN
KDRGPVAM

Download         Length: 267 bp

>AT155731 NZ_CP068813:c263254-263191 [Escherichia coli]
GTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K9QB06

Antitoxin

Source ID Structure
AlphaFold DB A0A2K9QKF2

References