155727

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higB-toxA/Tad-HTH_37
Location 434121..434749 Replicon chromosome
Accession NZ_CP052936
Organism Lacticaseibacillus paracasei strain CLP-C10

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HKJ34_RS02070 Protein ID WP_003583266.1
Coordinates 434381..434749 (-) Length 123 a.a.

Antitoxin (Protein)


Gene name toxA Uniprot ID -
Locus tag HKJ34_RS02065 Protein ID WP_003583264.1
Coordinates 434121..434381 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HKJ34_RS02040 (HKJ34_02090) 430012..430755 + 744 WP_003563368.1 SDR family oxidoreductase -
HKJ34_RS02045 (HKJ34_02095) 430868..431494 + 627 WP_003583257.1 flavodoxin -
HKJ34_RS02050 (HKJ34_02100) 431745..432248 + 504 WP_003583259.1 TetR/AcrR family transcriptional regulator -
HKJ34_RS02055 (HKJ34_02105) 432253..433314 + 1062 WP_003583262.1 ABC transporter permease -
HKJ34_RS02060 (HKJ34_02110) 433319..434008 + 690 WP_003583263.1 ABC transporter ATP-binding protein -
HKJ34_RS02065 (HKJ34_02115) 434121..434381 - 261 WP_003583264.1 helix-turn-helix transcriptional regulator Antitoxin
HKJ34_RS02070 (HKJ34_02120) 434381..434749 - 369 WP_003583266.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HKJ34_RS02075 (HKJ34_02125) 435040..436410 - 1371 WP_003573580.1 FAD-dependent oxidoreductase -
HKJ34_RS02080 (HKJ34_02130) 436774..437592 - 819 WP_011674103.1 Cof-type HAD-IIB family hydrolase -
HKJ34_RS02085 (HKJ34_02135) 437911..438180 - 270 WP_003563382.1 type II toxin-antitoxin system YafQ family toxin -
HKJ34_RS02090 (HKJ34_02140) 438421..439428 + 1008 WP_003563383.1 LacI family DNA-binding transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(34-112)

Antitoxin

Cro/C1-type helix-turn-helix domain

(28-79)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 14939.01 Da        Isoelectric Point: 8.3986

>T155727 WP_003583266.1 NZ_CP052936:c434749-434381 [Lacticaseibacillus paracasei]
MYKIDFYEDRDGYSEIEDFLDQLRHSHQKNNVSLLNKITKELYMLQNLGPRLREPHAKFLKGYAYPIMELRPMPERIFYA
AWQKDHFVLLHHYTKKTNKTDHREILRAQSNLEDWLSRKEEN

Download         Length: 369 bp

>T155727 NZ_CP068813:c72958-72584 [Escherichia coli]
ATGAAAACATTACCCGATACACTCGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACTCTGCTCTC
CCGACTGCTGGGCCAGCATTACGGCCTTACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACTTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9828.45 Da        Isoelectric Point: 10.2439

>AT155727 WP_003583264.1 NZ_CP052936:c434381-434121 [Lacticaseibacillus paracasei]
MTTWEDFSQKLKKDNPEKLAIIKTLADLESERIKQGISQKDFAEKIGMKQPQLAKIERLDSLPTLATLNRYARGLGKEIR
LSIVTQ

Download         Length: 261 bp

>AT155727 NZ_CP068813:c73416-73048 [Escherichia coli]
GTGTCAGACACACTCTCCGGGACAACGCATCCCGATGACAATCACGACCGTCCCTGGTGGGGACTACCCTGCACCGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGCAATCAGTTGCATTACCTTGCCGACCGCGCCGATATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAACGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References