Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 86692..87218 Replicon plasmid p3846III
Accession NZ_CP052873
Organism Enterobacter cloacae strain 3849

Toxin (Protein)


Gene name relE Uniprot ID A0A7R6HXL1
Locus tag HJI43_RS24345 Protein ID WP_015572079.1
Coordinates 86692..86979 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag HJI43_RS24350 Protein ID WP_000534858.1
Coordinates 86979..87218 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HJI43_RS24320 82088..82281 - 194 Protein_91 hypothetical protein -
HJI43_RS24325 82295..83170 - 876 Protein_92 IS3 family transposase -
HJI43_RS24330 83242..84410 + 1169 WP_096998908.1 IS3 family transposase -
HJI43_RS24335 84418..84700 - 283 Protein_94 transposase -
HJI43_RS24340 85320..85469 - 150 WP_158250578.1 hypothetical protein -
HJI43_RS24345 86692..86979 - 288 WP_015572079.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HJI43_RS24350 86979..87218 - 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
HJI43_RS24355 87393..88292 - 900 WP_045325182.1 LysR family transcriptional regulator -
HJI43_RS24360 88520..88870 + 351 WP_040171876.1 hypothetical protein -
HJI43_RS24365 88998..90215 + 1218 WP_072206003.1 MFS transporter -
HJI43_RS24370 90232..91278 + 1047 WP_045325187.1 NAD(P)-dependent alcohol dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..190697 190697


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11209.09 Da        Isoelectric Point: 10.0714

>T155693 WP_015572079.1 NZ_CP052873:c86979-86692 [Enterobacter cloacae]
MAYFLDFDERALKEWRKLGSTVREQLKNKLAEVLESPRIDANKLRGMHDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T155693 NZ_CP068811:c4710854-4710681 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT155693 WP_000534858.1 NZ_CP052873:c87218-86979 [Enterobacter cloacae]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT155693 NZ_CP068811:c4711178-4710882 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAATT
CCTTCGCAATAACGACATCATTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References