Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1786322..1786943 Replicon chromosome
Accession NZ_CP052870
Organism Enterobacter cloacae strain 3849

Toxin (Protein)


Gene name Hha Uniprot ID A0A837FFM2
Locus tag HJI43_RS08550 Protein ID WP_015571250.1
Coordinates 1786322..1786540 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID F5RUW7
Locus tag HJI43_RS08555 Protein ID WP_006809850.1
Coordinates 1786569..1786943 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HJI43_RS08520 1782334..1782594 + 261 WP_015571255.1 type B 50S ribosomal protein L31 -
HJI43_RS08525 1782597..1782737 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
HJI43_RS08530 1782734..1783444 - 711 WP_048966166.1 GNAT family N-acetyltransferase -
HJI43_RS08535 1783547..1785007 + 1461 WP_023299463.1 PLP-dependent aminotransferase family protein -
HJI43_RS08540 1784979..1785446 - 468 WP_048966010.1 membrane protein -
HJI43_RS08545 1785563..1786114 - 552 WP_048966011.1 maltose O-acetyltransferase -
HJI43_RS08550 1786322..1786540 - 219 WP_015571250.1 hemolysin expression modulator Hha Toxin
HJI43_RS08555 1786569..1786943 - 375 WP_006809850.1 Hha toxicity modulator TomB Antitoxin
HJI43_RS08560 1787453..1790599 - 3147 WP_023299464.1 multidrug efflux RND transporter permease subunit -
HJI43_RS08565 1790622..1791815 - 1194 WP_022647272.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8583.95 Da        Isoelectric Point: 8.9008

>T155678 WP_015571250.1 NZ_CP052870:c1786540-1786322 [Enterobacter cloacae]
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

>T155678 NZ_CP068811:2201793-2201896 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14497.28 Da        Isoelectric Point: 4.8989

>AT155678 WP_006809850.1 NZ_CP052870:c1786943-1786569 [Enterobacter cloacae]
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC

Download         Length: 375 bp

>AT155678 NZ_CP068811:c2201934-2201663 [Escherichia coli]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGCCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FFM2

Antitoxin

Source ID Structure
AlphaFold DB A0A837FGN8

References