Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 113606..114201 Replicon plasmid pBGHN1-1
Accession NZ_CP052865
Organism Burkholderia glumae strain HN1

Toxin (Protein)


Gene name chpB Uniprot ID C5AN78
Locus tag HJC54_RS12340 Protein ID WP_012734107.1
Coordinates 113851..114201 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID C5AN79
Locus tag HJC54_RS12335 Protein ID WP_012734108.1
Coordinates 113606..113857 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HJC54_RS12305 108707..109360 - 654 WP_161522129.1 SDR family oxidoreductase -
HJC54_RS12310 109365..109982 - 618 WP_169511694.1 NAD(P)H-dependent oxidoreductase -
HJC54_RS12315 110092..110526 + 435 WP_161522145.1 helix-turn-helix transcriptional regulator -
HJC54_RS12320 111111..111839 - 729 WP_012735342.1 IS6 family transposase -
HJC54_RS12325 111880..112833 + 954 Protein_112 tyrosine-type recombinase/integrase -
HJC54_RS12330 112918..113343 + 426 WP_169511695.1 hypothetical protein -
HJC54_RS12335 113606..113857 + 252 WP_012734108.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
HJC54_RS12340 113851..114201 + 351 WP_012734107.1 type II toxin-antitoxin system ChpB family toxin Toxin
HJC54_RS12345 114260..114406 + 147 WP_169511696.1 hypothetical protein -
HJC54_RS12350 114503..115548 + 1046 Protein_117 IS481 family transposase -
HJC54_RS12355 115825..116046 + 222 WP_017433768.1 hypothetical protein -
HJC54_RS12360 116269..116733 + 465 WP_012734106.1 Lrp/AsnC family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - fliL 1..185112 185112


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

Antitoxin PemI-like

(1-83)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12389.37 Da        Isoelectric Point: 8.8909

>T155675 WP_012734107.1 NZ_CP052865:113851-114201 [Burkholderia glumae]
MVKRVKFERGDIVRVSLSPTVGREQQGDFRPALVLSPAAFNALGVALVAPITQGGEFARFAGFAVPLSGSGTETQGVALV
NMVRMLDLEGRGARKIERAPVEVVEDALARLQTIIE

Download         Length: 351 bp

>T155675 NZ_CP068811:1952578-1952829 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 8940.31 Da        Isoelectric Point: 6.2420

>AT155675 WP_012734108.1 NZ_CP052865:113606-113857 [Burkholderia glumae]
MELKIQKWGNSAAVRLPSVLLEQINASVGGSLNADVRPDGVLLTPARRKYALDDLVAQCDTKAPVPADMAAWGEIKPVGR
EAW

Download         Length: 252 bp

>AT155675 NZ_CP068811:1952826-1953080 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAGTCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A246MF70

Antitoxin

Source ID Structure
AlphaFold DB A0A246MFN5

References