Detailed information of TA system TA155672

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-PumB/upstrm_HI1419-dnstrm_HI1420
• Location: 315646..316294
• Replicon: chromosome
• Accession: NZ_CP052863
• Organism: Stenotrophomonas maltophilia strain CF13

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HKK60_RS01340
• Protein ID: WP_169448014.1
• Coordinates: 315646..315933 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: PumB
• Uniprot ID: -
• Locus tag: HKK60_RS01345
• Protein ID: WP_169448015.1
• Coordinates: 315992..316294 (+)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HKK60_RS01335	311155..314886	-	3732	WP_169448013.1	hypothetical protein	-
HKK60_RS01340	315646..315933	+	288	WP_169448014.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HKK60_RS01345	315992..316294	+	303	WP_169448015.1	putative addiction module antidote protein	Antitoxin
HKK60_RS01350	316464..316865	-	402	Protein_268	hypothetical protein	-
HKK60_RS01355	317460..318230	+	771	WP_169448016.1	DUF3011 domain-containing protein	-
HKK60_RS01360	318255..318601	-	347	Protein_270	hypothetical protein	-
HKK60_RS01365	318732..319652	+	921	WP_005407709.1	arginase	-
HKK60_RS01370	319813..319950	+	138	WP_005407710.1	entericidin A/B family lipoprotein	-
HKK60_RS01375	320159..320380	+	222	WP_004153772.1	CsbD family protein	-
HKK60_RS01380	320454..321263	-	810	WP_169448017.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Addiction module killer protein, predicted (2-94)

Antitoxin

• Uncharacterized protein HI1420 (8-97)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 10710.29 Da
• Isoelectric Point: 10.5737

>T155672 WP_169448014.1 NZ_CP052863:315646-315933 [Stenotrophomonas maltophilia]
MKIQRTRQFGTCIDALKDVTGRARILARIGRLSEGHLGDHRYLADGVSELRIDVGPGYRVYYTQRGRQWVILLAGGDKGS
QQRDIEKAKELARAL

Nucleotide

• Length: 288 bp

>T155672 NZ_CP068811:972365-972772 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCCTGTTGATGGACGGGCGTTTGCGCTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 10724.42 Da
• Isoelectric Point: 10.0074

>AT155672 WP_169448015.1 NZ_CP052863:315992-316294 [Stenotrophomonas maltophilia]
MAIKKKVELKAFDVAEHLRTPKEMAAYLDACIEESDGDSAFIAKALGDIARAQGMSKVARAAGLSRESLYRALSGERSPD
FATILKVTRALGVRLRASAA

Nucleotide

• Length: 303 bp

>AT155672 NZ_CP068811:972118-972384 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGATGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA