Detailed information of TA system TA155670

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-yefM/YoeB-YefM
• Location: 5724637..5725142
• Replicon: chromosome
• Accession: NZ_CP052862
• Organism: Pseudomonas sp. ADAK2

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HKK52_RS26365
• Protein ID: WP_123410195.1
• Coordinates: 5724637..5724891 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: HKK52_RS26370
• Protein ID: WP_123410196.1
• Coordinates: 5724888..5725142 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HKK52_RS26335	5719728..5720435	+	708	WP_169373181.1	peptide-methionine (S)-S-oxide reductase MsrA	-
HKK52_RS26340	5720430..5720912	-	483	WP_169373182.1	GNAT family N-acetyltransferase	-
HKK52_RS26345	5720957..5721361	-	405	WP_169373183.1	GNAT family N-acetyltransferase	-
HKK52_RS26350	5721358..5722371	-	1014	WP_169373184.1	sensor domain-containing diguanylate cyclase	-
HKK52_RS26355	5722447..5723352	-	906	WP_169373185.1	LysR family transcriptional regulator	-
HKK52_RS26360	5723455..5724630	+	1176	WP_169373186.1	aspartate aminotransferase family protein	-
HKK52_RS26365	5724637..5724891	-	255	WP_123410195.1	Txe/YoeB family addiction module toxin	Toxin
HKK52_RS26370	5724888..5725142	-	255	WP_123410196.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
HKK52_RS26375	5725342..5725926	-	585	WP_169373187.1	DedA family protein	-
HKK52_RS26380	5725911..5726336	-	426	WP_169373188.1	VOC family protein	-
HKK52_RS26385	5726350..5726865	-	516	WP_169373189.1	adenylate kinase	-
HKK52_RS26390	5726874..5728775	-	1902	WP_169373190.1	alkaline phosphatase family protein	-
HKK52_RS26395	5729077..5729868	-	792	WP_169373191.1	VacJ family lipoprotein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-71)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 9966.44 Da
• Isoelectric Point: 8.9271

>T155670 WP_123410195.1 NZ_CP052862:c5724891-5724637 [Pseudomonas sp. ADAK2]
MNIEFTTEGWNDYLWFQQNDKAGLKRINLLIKAIQREPFSGPGKPEPLKHNLSGFWSRRITTEHRLVYAIEEGAIQIVMC
RYHY

Nucleotide

• Length: 255 bp

>T155670 NZ_CP068811:c676369-675905 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTACAGCGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAGACAGAAGAAGCCCATTGA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9442.86 Da
• Isoelectric Point: 8.5163

>AT155670 WP_123410196.1 NZ_CP052862:c5725142-5724888 [Pseudomonas sp. ADAK2]
MQTINYTTARAHLAETMDRVNEDRAPLLVTRQKGEPVVMMSLAEYNALEETAYLLRSPANAERLIKSIGNLRAGKAKARQ
LIEE

Nucleotide

• Length: 255 bp

>AT155670 NZ_CP068811:c676704-676369 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCGACACTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA