Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2878899..2879523 Replicon chromosome
Accession NZ_CP052862
Organism Pseudomonas sp. ADAK2

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag HKK52_RS13400 Protein ID WP_169371212.1
Coordinates 2878899..2879078 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag HKK52_RS13405 Protein ID WP_169371213.1
Coordinates 2879116..2879523 (+) Length 136 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HKK52_RS13375 2874725..2876212 + 1488 WP_169371208.1 sensor domain-containing diguanylate cyclase -
HKK52_RS13380 2876205..2876423 + 219 WP_169371209.1 cysteine-rich CWC family protein -
HKK52_RS13385 2876458..2877150 + 693 WP_169371210.1 pseudouridine synthase -
HKK52_RS13390 2877463..2878347 + 885 WP_169371211.1 alpha/beta hydrolase -
HKK52_RS13400 2878899..2879078 + 180 WP_169371212.1 type II toxin-antitoxin system HicA family toxin Toxin
HKK52_RS13405 2879116..2879523 + 408 WP_169371213.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
HKK52_RS13410 2880001..2880264 + 264 WP_123507545.1 short-chain dehydrogenase -
HKK52_RS13415 2880644..2881372 + 729 WP_169371214.1 class I SAM-dependent methyltransferase -
HKK52_RS13420 2881453..2882223 - 771 WP_169371215.1 trans-aconitate 2-methyltransferase -
HKK52_RS13425 2882618..2883121 + 504 WP_169371216.1 inclusion body family protein -
HKK52_RS13430 2883245..2883784 + 540 WP_169371217.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6723.00 Da        Isoelectric Point: 11.4113

>T155666 WP_169371212.1 NZ_CP052862:2878899-2879078 [Pseudomonas sp. ADAK2]
VNSRFLISQIVADGWYLVRIRGSHHHFKHPTKPGLVTVPHPKKDLLKKTAMSILQQALL

Download         Length: 180 bp

>T155666 NZ_CP068811:202744-202929 [Escherichia coli]
GTGAAAAGTGCAGACGTGATCGCCATCCTGAAGCAGCATGGCTGGGAACATATTCGAACCCGTGGCAGTCATCATCAGTT
CCGCCACCCTGTTCATCCGGGTCTGGTGACGGTTCCGCACCCTAAAAAAGATATTAAGCCCGGTACGCTGGCGCAAATTG
GGCGTCAGGCTGGTTTAACATTTTAA

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 14662.68 Da        Isoelectric Point: 4.4904

>AT155666 WP_169371213.1 NZ_CP052862:2879116-2879523 [Pseudomonas sp. ADAK2]
MLYPISISMGDDEHAWGVEVPDIPGCFSAGEDLDDAMAMAREAIEGHFEILAEDGSPIPPANKVTLHAANPKYAGCTWAL
VDIDVTKYLGKAQKLNITLPGYLLNRIDEYVLHHPEEKSRSGFLASAALKVLQQG

Download         Length: 408 bp

>AT155666 NZ_CP068811:202946-203356 [Escherichia coli]
ATGTTTTATCCCGCCTATATCCACAGTGATCCTGACGGCAGCGCCAGCGGTTTTTTCCCTGATGTTCCAGGCTGTTATTT
TGCTGGTGATACGCTGGACAACGCTTTCCAGGATGCGCGAAGTGCACTGGTCGCGCACTTCGAAACCTTATGCGAGATGA
ATGAAGAGTTGCCGCTTCCAGGCTCTGTGGAAACACATCTGGTCCAGCGTGCGCAGGACTTTATTGGTGGGCAATGGTTG
CTGGTGGATATCAATATGAATCAGTTCGAAGGTCGGGCTGAACGTATCAATATTACGATGCCGAAAAGGTTACTGAACAA
GATTGATACCTACGTGCGCAATAACCCAGACTACGCCAACAGAAGTGCGTTTCTGGCAGAAGCTGCCCGGCGTGTATTGC
CGGGCGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References