155665

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2571207..2571823 Replicon chromosome
Accession NZ_CP052862
Organism Pseudomonas sp. ADAK2

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag HKK52_RS12005 Protein ID WP_163909086.1
Coordinates 2571611..2571823 (-) Length 71 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag HKK52_RS12000 Protein ID WP_169370991.1
Coordinates 2571207..2571611 (-) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HKK52_RS11980 2567001..2567996 + 996 WP_149656989.1 sulfate ABC transporter substrate-binding protein -
HKK52_RS11985 2568208..2568837 - 630 WP_178117451.1 hypothetical protein -
HKK52_RS11990 2569072..2570277 + 1206 WP_169370989.1 MFS transporter -
HKK52_RS11995 2570308..2571147 + 840 WP_169370990.1 hypothetical protein -
HKK52_RS12000 2571207..2571611 - 405 WP_169370991.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
HKK52_RS12005 2571611..2571823 - 213 WP_163909086.1 type II toxin-antitoxin system HicA family toxin Toxin
HKK52_RS12010 2572046..2572702 + 657 WP_169370992.1 AhpC/TSA family protein -
HKK52_RS12015 2572751..2573470 + 720 WP_169370993.1 SDR family oxidoreductase -
HKK52_RS12020 2573630..2574517 + 888 WP_169370994.1 LysR family transcriptional regulator -
HKK52_RS12025 2574526..2574684 - 159 WP_169370995.1 hypothetical protein -
HKK52_RS12030 2574685..2575089 - 405 WP_169370996.1 hypothetical protein -
HKK52_RS12035 2575104..2576303 - 1200 WP_169370997.1 c-type cytochrome biogenesis protein CcmI -
HKK52_RS12040 2576296..2576769 - 474 WP_169370998.1 cytochrome c-type biogenesis protein CcmH -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 71 a.a.        Molecular weight: 7952.14 Da        Isoelectric Point: 9.9104

>T155665 WP_163909086.1 NZ_CP052862:c2571823-2571611 [Pseudomonas sp. ADAK2]
VQSRLLIKELEEAGWTLDRVTGSHHIFTHRYNPYTIPVPHPKKDLPIGTVKSIRRRAGLYCPPASYTGDP

Download         Length: 213 bp

>T155665 NZ_CP068811:c72957-72580 [Escherichia coli]
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTCACGCTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCATTTGTCCCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGACCCGCGA
CAATTACAGAATGGTAAATAACATTACCCAGGGTAAGCATCCGGAGGCGCAACAATGA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14771.80 Da        Isoelectric Point: 4.3937

>AT155665 WP_169370991.1 NZ_CP052862:c2571611-2571207 [Pseudomonas sp. ADAK2]
MQYPICIEWGDENTAIGIQIPDIPGAVTAGDTFEDAYNAAIEVAHVMLQEIAADGEPIPMPTSAAAHRGNPEFVDMGWGM
LELDIAPYMGKTEKVNVTLPGYVIQRIDRYVREHNVKSRSSFLADAAMEKLVRH

Download         Length: 405 bp

>AT155665 NZ_CP068811:c73415-73047 [Escherichia coli]
GTGTCAGACACACTGCCCGGGACAACGCATCCCGACGACAATCACGACCGCCTCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCAATGCAGATGCATACCACCTGGACCAGGCCTTTGCACTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References