Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09812-MazE
Location 3938992..3939623 Replicon chromosome
Accession NZ_CP052861
Organism Pseudomonas sp. ADAK7

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag HKK53_RS18090 Protein ID WP_169371957.1
Coordinates 3938992..3939354 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag HKK53_RS18095 Protein ID WP_169371958.1
Coordinates 3939354..3939623 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HKK53_RS18080 3934093..3937473 + 3381 WP_169371955.1 mechanosensitive channel MscK -
HKK53_RS18085 3937522..3938985 + 1464 WP_169371956.1 YdiU family protein -
HKK53_RS18090 3938992..3939354 - 363 WP_169371957.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
HKK53_RS18095 3939354..3939623 - 270 WP_169371958.1 PbsX family transcriptional regulator Antitoxin
HKK53_RS18100 3939894..3940328 + 435 WP_169371959.1 thioredoxin TrxC -
HKK53_RS18105 3940455..3941225 - 771 WP_054053184.1 ParA family protein -
HKK53_RS18110 3941582..3942307 + 726 WP_169374260.1 beta-ketoacyl synthase chain length factor -
HKK53_RS18115 3942283..3943092 + 810 WP_169371960.1 1-acyl-sn-glycerol-3-phosphate acyltransferase -
HKK53_RS18120 3943073..3943333 + 261 WP_169371961.1 acyl carrier protein -
HKK53_RS18125 3943343..3943597 + 255 WP_007992314.1 acyl carrier protein -
HKK53_RS18130 3943594..3944139 + 546 WP_169371962.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13164.05 Da        Isoelectric Point: 8.0621

>T155661 WP_169371957.1 NZ_CP052861:c3939354-3938992 [Pseudomonas sp. ADAK7]
MVRRQAPQRGDVFWIDPNPVAGREMMNRHRFVVITPRGINALGVSMTVPVTSGGSFSRNSGLAVVVTGHETNGVAVCNQV
RSFDIEQRVREGSAKFIERLDDVTMTDIIARVVSAIDPLD

Download         Length: 363 bp

>T155661 NZ_CP068810:c4672116-4671826 [Escherichia coli]
ATGAACTATGAGCTGGCGTTTGATCCGCGGGCGCTGAAAGAGTGGCAAAAACTGGGCGTGACAGTCCGGGAACAATTTAA
AAAAAAGCTTGAGGATGTGCTGAAAAGGCCGCGCAATCCATCGGCTAAACTGCGGGATTTACCGGACTGCTACAAAATTA
AGCTGCGCACACAGGGATATCGCCTGGTTTATCAGGTTAACGATAAAGAGTTGCTCGTGTTGGTGATAGCTATTGGTAAG
AGAGAGAACTCAGCCGTTTATGAAGACGCGACTAAACGGCTGGATGAGTGA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9692.11 Da        Isoelectric Point: 5.1316

>AT155661 WP_169371958.1 NZ_CP052861:c3939623-3939354 [Pseudomonas sp. ADAK7]
MSVTSKIRRQGGAAVITLPPTLLKLLHLEVGSQLELNVVDGELIARPVVKASRKRYSLDELLQGAEELAELNEQTAWARE
GDSVGRELG

Download         Length: 270 bp

>AT155661 NZ_CP068810:c4672348-4672106 [Escherichia coli]
ATGGCCACACTTAACGTCCGCCTGGATGACAAACTGAAAAATGAGGCTTATGCGGTGCTGGAAAAATTAAATATCACGCC
TACTGAAGCAGTGCGGCTGCTGTTTCAGTACGTTGCGGAAAATGGACGAATGCCGGTAAAAACGCTCACTGTCAGTGATA
GTGAAGAAGCCTTGTTACGCACTGTCAGGGAACGACTGGCCAACCCACAAGAGGCCATTAAGGTCCGACTGGATGAACTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References